Internal Fixation of Osteoporotic Bone

The Journal of the American Academy of Orthopaedic Surgeons
Kevin D GrantKevin C Baker

Abstract

Osteoporosis is one of the costliest conditions managed by orthopaedic surgeons. This condition, which is characterized by decreased bone density and thinning of cortical bone, is strongly influenced by complex signaling in both the hormonal and mechanical environments. Osteoporosis cannot be cured; instead, it can only be managed to decrease patient morbidity. Current pharmacologic treatments are aimed at minimizing bone turnover and have substantial side effects. Therefore, much work remains to find safer and more effective agents to restore bone density. In addition to the high incidence of fracture in elderly patients, many of the traditional fixation constructs used for repair of these fractures are not suitable for use in osteoporotic bone. Increased use of fixed-angle locking plates, intramedullary devices, and bone substitutes has greatly improved outcomes in these patients.

References

Jul 1, 1995·The Journal of Bone and Joint Surgery. American Volume·M R BaumgaertnerJ M Keggi
Apr 3, 2003·The Journal of the American Academy of Orthopaedic Surgeons·Charles N Cornell
Jun 8, 2006·The Journal of the American Academy of Orthopaedic Surgeons·Vonda J Wright
Dec 5, 2006·The Journal of Bone and Joint Surgery. American Volume·Shinya OkudaMotoki Iwasaki
Dec 6, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Russel BurgeAnna Tosteson
Jan 3, 2007·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·Todd KimChristian M Puttlitz
Jan 4, 2007·The Journal of Bone and Joint Surgery. American Volume·Antonio MoroniSandro Giannini
Jan 22, 2008·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Markus Wenger, Thomas-Marc Markwalder
Mar 5, 2008·Journal of Orthopaedic Trauma·Kenneth A EgolJoseph D Zuckerman
Sep 9, 2008·Journal of Orthopaedic Trauma·Earl R BogochDorcas E Beaton
Sep 16, 2008·The Spine Journal : Official Journal of the North American Spine Society·B G SantoniC M Puttlitz
Oct 2, 2008·Journal of Orthopaedic Trauma·Kenneth J WilkensMark A Lee
Aug 7, 2009·The New England Journal of Medicine·Rachelle BuchbinderBridie Murphy
Aug 7, 2009·The New England Journal of Medicine·David F KallmesJeffrey G Jarvik
Sep 9, 2009·Foot & Ankle International·Roy I DavidovitchKenneth A Egol
Nov 26, 2009·The Journal of Bone and Joint Surgery. American Volume·Richard M DellKathy Williams
May 4, 2010·The Journal of the American Academy of Orthopaedic Surgeons·Evan F Ekman
Jun 1, 2010·The Journal of the American Academy of Orthopaedic Surgeons·Michael J WeaverMark S Vrahas
Jul 3, 2010·The Journal of Bone and Joint Surgery. American Volume·Michael BottlangJ Lawrence Marsh
Aug 24, 2010·Journal of Biomechanics·Vincent A StadelmannDominique P Pioletti
Mar 4, 2011·The Journal of the American Academy of Orthopaedic Surgeons·Stephen I EssesKristin Hitchcock
Mar 29, 2011·The Journal of Bone and Joint Surgery. American Volume·Thomas MückleyGunther O Hofmann
Sep 15, 2011·The Journal of Bone and Joint Surgery. American Volume·Peter PeichlGerold Holzer
Jan 6, 2012·Clinical Orthopaedics and Related Research·Rahul VaidyaAdam J Starr
Mar 29, 2012·Journal of Spinal Disorders & Techniques·Kimihiko SawakamiNaoto Endo
Aug 15, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A SvedbomO Ström
Sep 21, 2012·The Journal of Bone and Joint Surgery. American Volume·Hyun Sik GongGoo Hyun Baek
Oct 26, 2012·The Journal of Bone and Joint Surgery. American Volume·Silvano AdamiDaniel Uebelhart
Apr 3, 2013·The Orthopedic Clinics of North America·Shah-Nawaz M Dodwad, Safdar N Khan
Aug 13, 2013·Geriatric Orthopaedic Surgery & Rehabilitation·Hitendra K DoshiDiarmuid Paul Murphy
Oct 4, 2013·The Journal of Bone and Joint Surgery. American Volume·Alexia KarantanaTim R C Davis
Jan 3, 2014·The New England Journal of Medicine·Michael R McClungHenry G Bone
Mar 1, 2014·The Journal of Hand Surgery·Shumaila SarfaniSanjeev Kakar
Jun 22, 2014·The Journal of Bone and Joint Surgery. American Volume·Franz KralingerBeate Hanson
Nov 27, 2014·Current Osteoporosis Reports·David L Rothberg, Mark A Lee
Nov 10, 2015·Journal of Tissue Engineering and Regenerative Medicine·Ulrike KettenbergerDominique P Pioletti

❮ Previous
Next ❯

Citations

Aug 17, 2018·The Journal of the American Academy of Orthopaedic Surgeons·Yu Cheng Lo
Aug 17, 2018·The Journal of the American Academy of Orthopaedic Surgeons·Kevin D GrantKevin C Baker
Jun 18, 2019·The Journal of the American Academy of Orthopaedic Surgeons·Geoffrey Marecek, Hugo Centomo
Nov 17, 2020·Journal of Clinical Orthopaedics and Trauma·Ramesh K SenNeha Raman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.