Internal ion-gated organic electrochemical transistor: A building block for integrated bioelectronics

Science Advances
George D SpyropoulosDion Khodagholy

Abstract

Real-time processing and manipulation of biological signals require bioelectronic devices with integrated components capable of signal amplification, processing, and stimulation. Transistors form the backbone of such circuits, but numerous criteria must be met for efficient and safe operation in biological environments. Here, we introduce an internal ion-gated organic electrochemical transistor (IGT) that uses contained mobile ions within the conducting polymer channel to permit both volumetric capacitance and shortened ionic transit time. The IGT has high transconductance, fast speed, and can be independently gated to create scalable conformable integrated circuits. We demonstrate the ability of the IGT to provide a miniaturized, comfortable interface with human skin using local amplification to record high-quality brain neurophysiological activity. The IGT is an effective transistor architecture for enabling integrated, real-time sensing and stimulation of signals from living organisms.

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Citations

Jun 18, 2019·Advanced Materials·Kyoseung SimCunjiang Yu
Mar 4, 2020·Advanced Materials·Alexander GiovannittiJonathan Rivnay
Jun 6, 2020·Advanced Materials·Kai XiaoMarkus Antonietti
Jun 23, 2020·Macromolecular Bioscience·Yang LiFabio Cicoira
Aug 31, 2020·Advanced Materials·Bryan D PaulsenJonathan Rivnay
Jan 26, 2020·Micromachines·Maria Laura ColuccioNatalia Malara
Mar 24, 2020·Nature Materials·Scott Keene, Yoeri van de Burgt
Mar 29, 2020·Nature Communications·Rachel A LucasZuzanna S Siwy
Jun 5, 2020·Science Advances·Patricia Jastrzebska-PerfectDion Khodagholy
Dec 12, 2020·Advanced Materials·Soh KushidaUwe H F Bunz
Jan 23, 2021·ACS Applied Materials & Interfaces·Saejin OhMichael L Chabinyc
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Sep 29, 2020·Advanced Drug Delivery Reviews·Dinorath Olvera, Michael G Monaghan
May 12, 2021·Proceedings of the National Academy of Sciences of the United States of America·Zifang ZhaoDion Khodagholy
May 19, 2021·ACS Sensors·Kyoung-Yong ChunChang-Soo Han
Jun 2, 2021·Advanced Materials·Letícia M M FerroCarlos C Bof Bufon
Jul 2, 2021·Biosensors & Bioelectronics·Reem B RashidJonathan Rivnay
Sep 10, 2020·ACS Applied Materials & Interfaces·Jingu KangSung Kyu Park
Aug 14, 2021·Nature Communications·Yuxin YangXing Fan
Aug 6, 2019·ACS Applied Materials & Interfaces·Rachel E OwyeungSameer R Sonkusale
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Sep 1, 2021·Macromolecular Bioscience·Yizhou ZhongSahika Inal
Oct 5, 2021·Advanced Materials·Ali NawazPrashant Sonar
Oct 6, 2021·Chemical Reviews·Anil KokluSahika Inal
Dec 16, 2021·Chemical Reviews·Charalampos PitsalidisRóisín M Owens
Jan 28, 2022·Advanced Science·Dickson R YaoDion Khodagholy
Jan 29, 2022·Chemical Reviews·Ivan B DimovIain McCulloch

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Methods Mentioned

BETA
scanning electron microscopy

Software Mentioned

MATLAB
RHD2000 Interface
Intan

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