Internal mammary sentinel nodes: ignore, irradiate or operate?

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Nathan J CoombsOwen A Ung

Abstract

This study describes the results of internal mammary chain (IMC) biopsy, identifying factors that predict 'hot spots' and nodal metastases for patients in whom mapped IMC nodes were routinely dissected. The nodal basin and status of every axillary and IMC site identified by lymphoscintigraphy were examined. Binary logistic regression analysed the relationship of several patients and tumour factors with IMC hot spots and metastases. Ninety of 490 patients (18.4%) had IMC sentinel lymph nodes (SLNs) identified by lymphatic mapping and dissected, and 20 of these (22.2%) were found to have metastases. Mapping to the IMC was most likely for women aged under 35 years (29.4%) (p=0.117), women aged 35-44 (22.6%) (p=0.034) or those with medial (23.7%) or central tumour location (22.2%) (p=0.014; p=0.062, respectively). Predictors of IMC positivity included age <35 years (p=0.063), grade 3 histology (p=0.018) and lymphatic vascular invasion (LVI) (p=0.032). Although IMC positivity was more likely with positive axillary nodes, this trend was not significant. We identified several factors (age <35 years, tumour grade and LVI) that independently predict IMC SLN identification and positivity for patients with stage I or II breast cancer. Whe...Continue Reading

References

Mar 1, 1977·The American Journal of Surgical Pathology·F A NimeJ A Urban
Jun 23, 2001·Annals of Surgery·F W van der EntA G Hoofwijk
Aug 29, 2003·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·M VictorzonA Lantto
Oct 7, 2003·Annals of Surgical Oncology·Susanne H EstourgieBin B R Kroon
Oct 24, 2006·ANZ Journal of Surgery·Sharon LauraJohn Boyages
May 10, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·U VeronesiR Orecchia

❮ Previous
Next ❯

Citations

Sep 21, 2013·Annals of Surgical Oncology·Abigail S CaudleKelly K Hunt
Aug 13, 2013·Pathology Oncology Research : POR·R MarázG Cserni
Jun 9, 2012·Breast Cancer Research and Treatment·E L PostmaA J Witkamp
Oct 9, 2015·Clinical Nuclear Medicine·Gianpiero MancaPatrick M Colletti
Feb 18, 2016·Nuclear Medicine Communications·Gianpiero MancaDuccio Volterrani
Nov 20, 2016·International Journal of Surgery·Mehdi Asadi, David Krag
Jul 12, 2017·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Ashley R CahoonWei T Yang
Oct 3, 2015·Tumori·Luigi De CiccoStefano Bracelli
Jan 7, 2011·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Qingqing HeXueliang Li
Mar 1, 2013·Journal of Medical Radiation Sciences·Wei Wang
Oct 11, 2017·The Medical Journal of Australia·John Boyages
Dec 17, 2009·Journal of Surgical Education·Ahmed Salem
Jul 14, 2010·Surgical Oncology Clinics of North America·Bijan Ansari, Judy C Boughey

❮ Previous
Next ❯

Related Concepts

Related Feeds

Absence Epilepsy

Absence epilepsy is a common seizure disorder in children which can produce chronic psychosocial sequelae. Discover the latest research on absence epilepsies here.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

© 2021 Meta ULC. All rights reserved