Internal microdosimetry of alpha-emitting radionuclides

Radiation and Environmental Biophysics
Werner HofmannI Balásházy

Abstract

At the tissue level, energy deposition in cells is determined by the microdistribution of alpha-emitting radionuclides in relation to sensitive target cells. Furthermore, the highly localized energy deposition of alpha particle tracks and the limited range of alpha particles in tissue produce a highly inhomogeneous energy deposition in traversed cell nuclei. Thus, energy deposition in cell nuclei in a given tissue is characterized by the probability of alpha particle hits and, in the case of a hit, by the energy deposited there. In classical microdosimetry, the randomness of energy deposition in cellular sites is described by a stochastic quantity, the specific energy, which approximates the macroscopic dose for a sufficiently large number of energy deposition events. Typical examples of the alpha-emitting radionuclides in internal microdosimetry are radon progeny and plutonium in the lungs, plutonium and americium in bones, and radium in targeted radionuclide therapy. Several microdosimetric approaches have been proposed to relate specific energy distributions to radiobiological effects, such as hit-related concepts, LET and track length-based models, effect-specific interpretations of specific energy distributions, such as th...Continue Reading

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Methods Mentioned

BETA
gamma ray
irradiating
biopsy
chromosomal aberrations
chromosomal aberration

Related Concepts

Americium
Cell Nucleus
Lung
Plutonium
Radiobiology
Radioisotopes
Radionuclide Therapy
Skeletal Bone
Therapy, low-LET Implant
Particle

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