At the tissue level, energy deposition in cells is determined by the microdistribution of alpha-emitting radionuclides in relation to sensitive target cells. Furthermore, the highly localized energy deposition of alpha particle tracks and the limited range of alpha particles in tissue produce a highly inhomogeneous energy deposition in traversed cell nuclei. Thus, energy deposition in cell nuclei in a given tissue is characterized by the probability of alpha particle hits and, in the case of a hit, by the energy deposited there. In classical microdosimetry, the randomness of energy deposition in cellular sites is described by a stochastic quantity, the specific energy, which approximates the macroscopic dose for a sufficiently large number of energy deposition events. Typical examples of the alpha-emitting radionuclides in internal microdosimetry are radon progeny and plutonium in the lungs, plutonium and americium in bones, and radium in targeted radionuclide therapy. Several microdosimetric approaches have been proposed to relate specific energy distributions to radiobiological effects, such as hit-related concepts, LET and track length-based models, effect-specific interpretations of specific energy distributions, such as th...Continue Reading
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Absorbed fraction of alpha-particles emitted in bifurcation regions of the human tracheo-bronchial tree
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Non-linear relationship of cell hit and transformation probabilities in a low dose of inhaled radon progenies
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Evidence of extranuclear cell sensitivity to alpha-particle radiation using a microdosimetric model. II. Application of the microdosimetric model to experimental results
MIRD Pamphlet No. 22 (abridged): radiobiology and dosimetry of alpha-particle emitters for targeted radionuclide therapy
Stochastic simulation of DNA double-strand break repair by non-homologous end joining based on track structure calculations
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Track structures, DNA targets and radiation effects in the biophysical Monte Carlo simulation code PARTRAC
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Track structure based modelling of chromosome aberrations after photon and alpha-particle irradiation
Dose and Time Dependence of Targeted and Untargeted Effects after Very Low Doses of α-Particle Irradiation of Human Lung Cancer Cells
Redefining relative biological effectiveness in the context of the EQDX formalism: implications for alpha-particle emitter therapy
Biophysical modelling of the effects of inhaled radon progeny on the bronchial epithelium for the estimation of the relationships applied in the two-stage clonal expansion model of carcinogenesis
DNA strand breaks induced by electrons simulated with Nanodosimetry Monte Carlo Simulation Code: NASIC
Chromosome aberration model combining radiation tracks, chromatin structure, DSB repair and chromatin mobility
A Monte Carlo approach to small-scale dosimetry of solid tumour microvasculature for nuclear medicine therapies with (223)Ra-, (131)I-, (177)Lu- and (111)In-labelled radiopharmaceuticals
Quantitative single-particle digital autoradiography with α-particle emitters for targeted radionuclide therapy using the iQID camera
Mechanistic study on lung cancer mortality after radon exposure in the Wismut cohort supports important role of clonal expansion in lung carcinogenesis
Radon induced hyperplasia: effective adaptation reducing the local doses in the bronchial epithelium
Comprehensive track-structure based evaluation of DNA damage by light ions from radiotherapy-relevant energies down to stopping
Targeted α-Therapy of Metastatic Castration-Resistant Prostate Cancer with 225 Ac-PSMA-617: Dosimetry Estimate and Empiric Dose Finding
Track to the future: historical perspective on the importance of radiation track structure and DNA as a radiobiological target.
Radiation Imagers for Quantitative, Single-particle Digital Autoradiography of Alpha- and Beta-particle Emitters
Effects of mucus thickness and goblet cell hyperplasia on microdosimetric quantities characterizing the bronchial epithelium upon radon exposure
QUANTITATIVE ANALYSIS OF THE POTENTIAL ROLE OF BASAL CELL HYPERPLASIA IN THE RELATIONSHIP BETWEEN CLONAL EXPANSION AND RADON CONCENTRATION
Microdosimetry-based determination of tumour control probability curves for treatments with225Ac-PSMA of metastatic castration resistant prostate cancer.
Development of patient-specific 3D models from histopathological samples for applications in radiation therapy.
Calculation of microdosimetric spectra for protons using Geant4-DNA and a μ-randomness sampling algorithm for the nanometric structures.
A simple technique for measuring the activity size distribution of radon and thoron progeny aerosols.
A Paradigm Revolution or Just Better Resolution-Will Newly Emerging Superresolution Techniques Identify Chromatin Architecture as a Key Factor in Radiation-Induced DNA Damage and Repair Regulation?
Microdosimetry-based determination of tumour control probability curves for treatments with 225Ac-PSMA of metastatic castration resistant prostate cancer.
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