Internal quality control and external quality assurance in testing for antiphospholipid antibodies: Part II--Lupus anticoagulant

Seminars in Thrombosis and Hemostasis
Emmanuel J FavaloroKatherine Marsden

Abstract

In addition to the presence of appropriate clinical features, the diagnosis of the antiphospholipid antibody syndrome (APS) fundamentally requires the finding of positive antiphospholipid antibody (aPL) test result(s), with these comprising clot-based assays for the identification of lupus anticoagulant (LA) and immunologic ("solid-phase") assays such as anticardiolipin antibodies (aCL) and anti-β2-glycoprotein I antibodies (aβ2GPI). This article is the second of two that review the process for, and provide recommendations to improve, internal quality control (IQC) and external quality assurance (EQA; or proficiency testing) for aPL assays. These processes are critical for ensuring the quality of laboratory test results, and thence the appropriate clinical diagnosis and management of APS. This article covers LA testing. We provide some updated findings from the Royal College of Pathologists of Australasia Haematology Quality Assurance Program, and cover testing results for the past 3 years (2009 to 2011 inclusive). In brief: (1) essentially all laboratories currently perform LA testing using activated partial thromboplastin time (APTT) and dilute Russell viper venom time (dRVVT) methods, and about one-third also employ the kaol...Continue Reading

Citations

Apr 17, 2013·International Journal of Colorectal Disease·Simone SaibeniMiquel Sans
Aug 6, 2013·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Emmanuel J FavaloroKatherine Marsden
Jun 29, 2012·Haemophilia : the Official Journal of the World Federation of Hemophilia·T W BarrowcliffeS Kitchen
Apr 18, 2013·International Journal of Laboratory Hematology·E J Favaloro
Apr 23, 2014·International Journal of Laboratory Hematology·K M J Devreese
Feb 20, 2015·Hematology·Steven A Krilis, Bill Giannakopoulos
May 25, 2018·Platelets·Emmanuel J Favaloro, Roslyn Bonar
Jul 5, 2019·Journal of Thrombosis and Haemostasis : JTH·Hannah CohenUNKNOWN International Society for Thrombosis and Haemostasis Scientific and Standardization Committee for Lupus Anticoagulant/Antiph
Oct 18, 2012·Clinical Chemistry and Laboratory Medicine : CCLM·Emmanuel J Favaloro
Aug 26, 2014·Clinical Chemistry and Laboratory Medicine : CCLM·Paul FroomMira Barak
May 3, 2018·Frontiers in Medicine·Stephanie A SmithJames H Morrissey
Aug 6, 2019·American Journal of Hematology·Emmanuel J Favaloro
Jun 21, 2020·Current Rheumatology Reports·Katrien M J Devreese
Sep 15, 2015·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Alessandra PozRoberta Giacomello
Sep 14, 2019·Journal of Thrombosis and Haemostasis : JTH·Walid ChayouaKatrien M J Devreese
Mar 19, 2021·Research and Practice in Thrombosis and Haemostasis·Steven Andrew BakerJames L Zehnder
Aug 2, 2017·The American Journal of the Medical Sciences·Ke YaoDengju Li
Jun 16, 2021·Seminars in Thrombosis and Hemostasis·Emmanuel J FavaloroGiuseppe Lippi
Jul 15, 2021·Seminars in Thrombosis and Hemostasis·Gábor SzabóJános Kappelmayer

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