PMID: 2116901Jun 26, 1990Paper

Internal transcribed spacer 1 of the yeast precursor ribosomal RNA. Higher order structure and common structural motifs

Biochemistry
L C YehJ C Lee

Abstract

The higher order structure of the first internal transcribed spacer between the 18S and the 5.8S rRNA sequences in the Saccharomyces cerevisiae precursor ribosomal RNA has been investigated. Sites of potential base pairing in the RNA region have been determined by using a combination of enzymatic and chemical structure sensitive probes. Data generated have been used to evaluate secondary structure models predicted by minimum free energy calculations. Several alternative suboptimal structures were also evaluated. The derived model contains several stable hairpins. Theoretical secondary structural models for the corresponding RNA region from S. carlsbergensis, S. pombe, N. crassa, X. laevis, and mung bean have also been derived from identical calculations and assumptions. Certain structural motifs appear to be conserved despite extensive divergence in the base sequence. The yeast model should be a useful prototype for investigation of structure and function of precursor ribosomal RNA molecules.

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Citations

Oct 1, 1994·Plant Molecular Biology·J S Liu, C L Schardl
Nov 1, 1992·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·O Y Kwon, H Ishikawa
Jul 4, 2012·Nature Structural & Molecular Biology·Simon LebaronDavid Tollervey
Aug 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·Allison C Lamanna, Katrin Karbstein
Aug 15, 1996·Nucleic Acids Research·J R ChamberlainD R Engelke
Mar 29, 2000·Nucleic Acids Research·C AllmangD Tollervey
Jun 22, 2013·Nucleic Acids Research·Jill A DembowskiJohn L Woolford
Nov 1, 1995·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·R W van NuesH A Raué
Aug 11, 2005·Canadian Journal of Microbiology·D-M Wang, Y-J Yao
Jul 28, 2004·Journal of Molecular Biology·Scott C Walker, Johanna M Avis
Oct 21, 2014·Wiley Interdisciplinary Reviews. RNA·Antonio Fernández-PevidaJesús de la Cruz
May 18, 1999·American Journal of Botany·D S Gernandt, A Liston
Nov 20, 2002·The Journal of Biological Chemistry·Joanna KufelDavid Tollervey
Nov 24, 1999·Molecular and Cellular Biology·D KresslerJ de La Cruz

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