Internal transcribed spacer regions of rRNA genes of Pneumocystis carinii from monkeys

Clinical and Diagnostic Laboratory Immunology
J Y HsuehC H Lee

Abstract

Analysis of sequence variations among isolates of Pneumocystis carinii f. sp. macacae from 14 Indian rhesus monkeys (Macaca mulatta) at the internal transcribed spacer (ITS) regions of the nuclear rRNA gene was undertaken. Like those from P. carinii f. sp. hominis, the ITS sequences from various P. carinii f. sp. macacae isolates were not identical. Two major types of sequences were found. One type of sequence was shared by 13 isolates. These 13 sequences were homologous but not identical. Variations were found at 13 of the 180 positions in the ITS1 region and 28 of the 221 positions in the ITS2 region. These sequence variations were not random but exhibited definite patterns when the sequences were aligned. According to this sequence variation, ITS1 sequences were classified into three types and ITS2 sequences were classified into five types. The remaining specimen had ITS1 and ITS2 sequences substantially different from the others. Although some specimens had the same ITS1 or ITS2 sequence, all 14 samples exhibited a unique whole ITS sequence (ITS1 plus ITS2). The 5.8S rRNA gene sequences were also analyzed, and only two types of sequences that differ by only one base were found. Unlike P. carinii f. sp. hominis infections in...Continue Reading

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Citations

May 4, 2004·Molecular Phylogenetics and Evolution·Jacques GuillotRené Chermette
Sep 1, 1996·The Journal of Eukaryotic Microbiology·C H LeeJ W Smith
Mar 22, 2002·The Journal of Eukaryotic Microbiology·S R MeshnickL Huang
Apr 9, 2004·Journal of Clinical Microbiology·Frans J L RobbertsLynda J Chalkley
May 1, 2009·Enfermedades infecciosas y microbiología clínica·Gustavo WissmannJose M Varela
Jun 21, 2008·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Cécile-Marie Aliouat-DenisEduardo Dei-Cas
Jan 31, 2006·The Journal of Eukaryotic Microbiology·Scott A RedheadJames R Stringer
Jun 27, 2014·The Journal of Eukaryotic Microbiology·Christiane Weissenbacher-LangHerbert Weissenböck

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