Abstract
Scavenger receptors (SRs) are a family of receptors displaying affinity for a wide variety of ligands including modified lipoproteins. SRs may play a range of physiological functions including intracellular transport, lipid transport and pathogen clearance. The role of SRs has been documented in pathologies such as atherosclerosis and Alzheimer's disease. Although most studies on SRs have focused on macrophages, they are also present in other cells like endothelium, smooth muscles and brain tissue. Within brain, due to its functional similarity, SRs have been studied mostly in microglia. However, in situ images from Allen's brain atlas suggest SRs are abundant in neurons. In this study we have used two fluorophore labeled well characterized SR ligand, maleylated-BSA (MBSA) and polyguanylic acid (poloyG) to probe acute cortical slices. Our data indicate that within cortex, neurons avidly endocytose both ligands. Thus in cerebral cortex neurons may have higher number of functional SRs on the surface than other cell-types.
References
Jan 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J L GoldsteinM S Brown
May 12, 1989·Science·A MukhopadhyayS K Basu
Jan 1, 1980·Journal of Supramolecular Structure·M S BrownJ L Goldstein
Aug 26, 1998·Chemistry & Biology·N Platt, S Gordon
Jun 25, 1999·Cell·M TrommsdorffJ Herz
Nov 7, 1999·The Journal of Biological Chemistry·H StanglH H Hobbs
Aug 21, 2002·Journal of Cell Science·Konark MukherjeeAmitabha Mukhopadhyay
Jan 8, 2004·The Journal of Biological Chemistry·Hideki HayashiJean E Vance
Jul 1, 2005·The Journal of Biological Chemistry·Rodrigo AlarcónRommy von Bernhardi
Jan 5, 2011·International Journal of Alzheimer's Disease·Aaron Y Lai, Joanne McLaurin
Feb 26, 2011·Immunological Reviews·Annette PlüddemannSiamon Gordon
Apr 11, 2014·PloS One·He ZhangRui-tian Liu
May 27, 2015·Cells·Izma Abdul ZaniSreenivasan Ponnambalam