PMID: 3750316Jan 1, 1986Paper

Internalized proteins directed into accumulative compartments of mosquito oocytes by the specific ligand, vitellogenin

Tissue & Cell
A S Raikhel, A O Lea

Abstract

We have investigated the internalization pathways for a specific protein, vitellogenin, and a non-specific protein, horseradish peroxidase, in the mosquito oocyte in vivo. The internalized proteins were localized by electron microscopical immunocytochemistry or autoradiography; the relationship of their destination compartments with lysosomes was monitored by visualization of acid phosphatase. Proteins internalized by the oocyte follow either a specific accumulative route or a lysosomal degradative route. Via coated vesicles, both proteins enter the same compartment, the endosome, where they dissociate from membrane-binding sites. The route to their final destination depends on the presence of the specific ligand. In its absence, the degradative route is followed, and the endosome with non-specific protein fuses with lysosomes. In the presence of the specific ligand, the accumulative route is followed, and both specific and non-specific proteins are delivered into an accumulative compartment, the transitional yolk body. During the transformation of the transitional yolk body into the final storage compartment, a mature yolk body, vitellogenin undergoes crystallization, whereas the non-specific protein is concentrated in small v...Continue Reading

References

Jun 21, 1979·Nature·J L GoldsteinM S Brown
Mar 1, 1985·General and Comparative Endocrinology·A S Raikhel, A O Lea
Nov 1, 1985·The Journal of Cell Biology·D A Wall, I Meleka
Oct 1, 1972·The Journal of Cell Biology·R M Steinman, Z A Cohn
Mar 15, 1972·Journal of Medical Entomology·R Meola, A O Lea
Apr 1, 1966·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·R C Graham, M J Karnovsky
Oct 30, 1981·Science·I H Pastan, M C Willingham
Jan 1, 1983·The Journal of Cell Biology·R M SteinmanZ A Cohn
Oct 1, 1983·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J M Robinson, M J Karnovsky

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Citations

Jan 22, 1998·Archives of Insect Biochemistry and Physiology·S J SeoH R Kim
Jan 1, 1991·Archives of Insect Biochemistry and Physiology·T S Dhadialla, A S Raikhel
Feb 1, 1994·International Journal for Parasitology·J R SauerR C Essenberg
Jul 12, 2002·Insect Biochemistry and Molecular Biology·Eliane FialhoMário A C Silva-Neto
Nov 18, 1998·Insect Biochemistry and Molecular Biology·H L HandleyJ T Bradley
May 29, 2002·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·A H WarnerG Criel
Feb 26, 2000·Molecular Biology of the Cell·C P SchonbaumA P Mahowald
Aug 22, 2006·Archives of Insect Biochemistry and Physiology·D M P Oliveira, E A Machado
Feb 1, 2005·Insect Biochemistry and Molecular Biology·Dennis Van HoofDick J Van der Horst
Oct 1, 1990·Roux's Archives of Developmental Biology : the Official Organ of the EDBO·Alan R Hays, Alexander S Raikhel

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