Apr 18, 2008

Internally coated endotracheal tubes with silver sulfadiazine in polyurethane to prevent bacterial colonization: a clinical trial

Intensive Care Medicine
Lorenzo BerraAntonio Pesenti

Abstract

Coated medical devices have been shown to reduce catheter-related infections. We coated endotracheal tubes (ETT) with silver sulfadiazine (SSD), and tested them in a clinical study to assess the feasibility, safety, and efficacy of preventing bacterial colonization. A prospective, randomized clinical trial, phase I-II. Academic intensive care unit (ICU). Forty-six adult patients expected to need 12-24 h of intubation were randomized into two groups. Patients were randomized to be intubated with a standard non-coated ETT (St-ETT, n=23; control group), or with a SSD-coated ETT (SSD-ETT, n=23). Coating with SSD prevented bacterial colonization of the ETT (frequency of colonization: SSD-ETT 0/23, St-ETT 8/23; p<0.01). No organized bacterial biofilm could be identified on the lumen of any ETT; however, SSD was associated with a thinner mucus layer (in the SSD-ETT secretion deposits ranged from 0 to 200 microm; in the St-ETT deposits ranged between 50 and 700 microm). No difference was observed between the two groups in the tracheobronchial brush samples (frequency of colonization: SSD-ETT 0/23, St-ETT 2/23; p=0.48). No adverse reactions were observed with the implementation of the novel device. SSD-ETT can be safely used in preventi...Continue Reading

  • References28
  • Citations26

References

Mentioned in this Paper

SSD
Entire Lumen of Body System
Coated Materials, Biocompatible
Spastic Paraplegia 17
Clinical Trials, Randomized
Process of Secretion
Biocides
Intubation, Intratracheal
Mucus Layer
Spandex

Related Feeds

Biofilm & Infectious Disease

Biofilm formation is a key virulence factor for a wide range of microorganisms that cause chronic infections.Here is the latest research on biofilm and infectious diseases.