Apr 18, 2008

Internally coated endotracheal tubes with silver sulfadiazine in polyurethane to prevent bacterial colonization: a clinical trial

Intensive Care Medicine
Lorenzo BerraAntonio Pesenti


Coated medical devices have been shown to reduce catheter-related infections. We coated endotracheal tubes (ETT) with silver sulfadiazine (SSD), and tested them in a clinical study to assess the feasibility, safety, and efficacy of preventing bacterial colonization. A prospective, randomized clinical trial, phase I-II. Academic intensive care unit (ICU). Forty-six adult patients expected to need 12-24 h of intubation were randomized into two groups. Patients were randomized to be intubated with a standard non-coated ETT (St-ETT, n=23; control group), or with a SSD-coated ETT (SSD-ETT, n=23). Coating with SSD prevented bacterial colonization of the ETT (frequency of colonization: SSD-ETT 0/23, St-ETT 8/23; p<0.01). No organized bacterial biofilm could be identified on the lumen of any ETT; however, SSD was associated with a thinner mucus layer (in the SSD-ETT secretion deposits ranged from 0 to 200 microm; in the St-ETT deposits ranged between 50 and 700 microm). No difference was observed between the two groups in the tracheobronchial brush samples (frequency of colonization: SSD-ETT 0/23, St-ETT 2/23; p=0.48). No adverse reactions were observed with the implementation of the novel device. SSD-ETT can be safely used in preventi...Continue Reading

  • References28
  • Citations26


Mentioned in this Paper

Entire Lumen of Body System
Coated Materials, Biocompatible
Spastic Paraplegia 17
Clinical Trials, Randomized
Process of Secretion
Intubation, Intratracheal
Mucus Layer

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