Internally Generated Predictions Enhance Neural and Behavioral Detection of Sensory Stimuli in an Electric Fish

Neuron
Armen G EnikolopovNathaniel B Sawtell

Abstract

Studies of cerebellum-like circuits in fish have demonstrated that synaptic plasticity shapes the motor corollary discharge responses of granule cells into highly-specific predictions of self-generated sensory input. However, the functional significance of such predictions, known as negative images, has not been directly tested. Here we provide evidence for improvements in neural coding and behavioral detection of prey-like stimuli due to negative images. In addition, we find that manipulating synaptic plasticity leads to specific changes in circuit output that disrupt neural coding and detection of prey-like stimuli. These results link synaptic plasticity, neural coding, and behavior and also provide a circuit-level account of how combining external sensory input with internally generated predictions enhances sensory processing.

Citations

Mar 13, 2019·ELife·Conor DempseyNathaniel B Sawtell
Feb 23, 2020·Annual Review of Neuroscience·Jeffrey C Magee, Christine Grienberger
Oct 2, 2019·Frontiers in Integrative Neuroscience·Volker Hofmann, Maurice J Chacron
Jul 25, 2019·Frontiers in Human Neuroscience·Jed D BurgessPeter G Enticott
Nov 19, 2019·Cell·Salomon Z MullerNathaniel B Sawtell
Nov 10, 2021·The Journal of Experimental Biology·Te K JonesCynthia F Moss

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