International Active Surveillance Study of Women Taking Oral Contraceptives (INAS-OC Study).

BMC Medical Research Methodology
Juergen C DingerAnita Assmann

Abstract

A 24-day regimen of contraceptive doses of drospirenone and ethinylestradiol (DRSP/EE 24d) was recently launched. This regimen has properties which may be beneficial for certain user populations (e.g., women suffering from premenstrual dysphoric disorder or acne). However, it is unknown whether this extended regimen has an impact on the cardiovascular risk associated with the use of oral contraceptives (OCs). The INternational Active Surveillance study of women taking Oral Contraceptives (INAS-OC) is designed to investigate the short- and long-term safety of the new regimen in a population which is representative for the typical user of oral contraceptives. A large, prospective, controlled, non-interventional, long-term cohort study with active surveillance of the study participants has been chosen to ensure reliable and valid results. More than 2,000 gynecologists in the US and 5 European countries (Austria, Germany, Italy, Poland, and Sweden) will recruit more than 80,000 OC users. The two to five year follow-up of these women will result in at least 220,000 documented women-years. The main clinical outcomes of interest for the follow-up are deep venous thrombosis, pulmonary embolism, acute myocardial infarction and cerebrova...Continue Reading

References

Apr 1, 1991·American Journal of Epidemiology·M Susser
Nov 25, 1997·American Journal of Obstetrics and Gynecology·J P VandenbrouckeF R Rosendaal
Feb 1, 2000·Human Reproduction Update·L A Heinemann
Jun 15, 2000·American Journal of Epidemiology·S Shapiro
Jul 21, 2001·BMJ : British Medical Journal·J M KemmerenD E Grobbee
Aug 31, 2002·Human Reproduction·Walter O SpitzerKenneth D MacRae
Sep 4, 2007·Obstetrics and Gynecology·John D SeegerAlexander M Walker
Aug 15, 2009·BMJ : British Medical Journal·Øjvind LidegaardCarsten Agger
Oct 24, 2009·The Journal of Family Planning and Reproductive Health Care·Jürgen Dinger

❮ Previous
Next ❯

Citations

Aug 20, 2011·JAAPA : Official Journal of the American Academy of Physician Assistants·Jennifer Hofmann Ribowsky
Jul 5, 2015·Thrombosis Research·Adnan I QureshiM Fareed K Suri
Aug 15, 2012·Contraception·Jeffrey T Jensen, James Trussell
Oct 23, 2012·Acta Obstetricia Et Gynecologica Scandinavica·Lene HeeMogens Vejtorp
Oct 18, 2016·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Clare BarnettKlaas Heinemann
May 20, 2011·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Dana A Brown, Christine M Vartan
Jun 18, 2019·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Clare BarnettKlaas Heinemann
Dec 29, 2021·JAMA : the Journal of the American Medical Association·Stephanie Teal, Alison Edelman

❮ Previous
Next ❯

Methods Mentioned

BETA
imaging procedure

Software Mentioned

SAS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.