International clinical experience with azlocillin

The Journal of Antimicrobial Chemotherapy
P SchachtD Tettenborn


Clinical studies with azlocillin were conducted in North America and Europe to assess its efficacy and to monitor its safety. The results of studies from these two areas are compared retrospectively. In North America 631 multiple-dose courses were monitored, while 887 were given in Europe. The most frequently administered daily dose was 18 g in North America and 15 g in Europe. In 71% of the courses a Pseudomonas species was the causative infecting organism in the former area and 51% in the latter. Over 60% of the patients were seriously ill, and about a third were over 60 years of age. A satisfactory bacteriological response, as defined by the eradication or a marked reduction of the organism causing infection was obtained in 74% of patients in North America and in 75% in Europe. 89% of the patients in America responded clinically compared to 92% in Europe. Ps. aeruginosa was eradicated in over 70% of instances. Azlocillin, like other penicillins, possesses a low potential for toxicity. Hypersensitivity reactions and gastrointestinal effects were the most common adverse experiences. No serious problems were encountered with impairment of renal or hepatic function, or blood coagulation. Azlocillin was effective for treating ser...Continue Reading


Sep 1, 1984·Antimicrobial Agents and Chemotherapy·J T SummersgillM J Raff
May 1, 1989·Antimicrobial Agents and Chemotherapy·R D LanderD R Pyszczynski

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Azlocillin sodium
Bacterial Infections
Upper Respiratory Infections
Urinary Tract Infection

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