International consensus on preliminary definitions of improvement in adult and juvenile myositis

Arthritis and Rheumatism
Lisa G RiderInternational Myositis Assessment and Clinical Studies Group

Abstract

To use a core set of outcome measures to develop preliminary definitions of improvement for adult and juvenile myositis as composite end points for therapeutic trials. Twenty-nine experts in the assessment of myositis achieved consensus on 102 adult and 102 juvenile paper patient profiles as clinically improved or not improved. Two hundred twenty-seven candidate definitions of improvement were developed using the experts' consensus ratings as a gold standard and their judgment of clinically meaningful change in the core set of measures. Seventeen additional candidate definitions of improvement were developed from classification and regression tree analysis, a data-mining decision tree tool analysis. Six candidate definitions specifying percentage change or raw change in the core set of measures were developed using logistic regression analysis. Adult and pediatric working groups ranked the 13 top-performing candidate definitions for face validity, clinical sensibility, and ease of use, in which the sensitivity and specificity were >/=75% in adult, pediatric, and combined data sets. Nominal group technique was used to facilitate consensus formation. The definition of improvement (common to the adult and pediatric working groups)...Continue Reading

Associated Clinical Trials

Jul 24, 2013·Rohit Aggarwal, MD, Rohit Aggarwal, MD
Nov 3, 2015·Rodolfo Curiel

References

Feb 1, 1980·Arthritis and Rheumatism·J F FriesH R Holman
Dec 1, 1994·Arthritis and Rheumatism·G SinghD P Goldsmith
Jul 1, 1997·Arthritis and Rheumatism·E H GianniniA Martini
Jul 6, 2000·Baillière's Best Practice & Research. Clinical Rheumatology·L G Rider, F W Miller
Nov 16, 2001·Rheumatology·F W MillerUNKNOWN International Myositis Outcome Assessment Collaborative Study Group
Jan 1, 2003·Rheumatic Diseases Clinics of North America·Lisa G Rider
Jan 1, 2003·Rheumatic Diseases Clinics of North America·Chester V Oddis
May 31, 2003·Nature Reviews. Drug Discovery·Josef S Smolen, Günter Steiner
Jul 2, 2003·Rheumatology·Nicolino RupertoUNKNOWN Pediatric Rheumatology Collaborative Study Group (PRCSG)
Jan 11, 2005·Rheumatology·R A Watts

❮ Previous
Next ❯

Citations

Nov 26, 2010·European Journal of Clinical Pharmacology·Nicolino RupertoUNKNOWN Paediatric Rheumatology International Trials Organisation (PRINTO)
Nov 14, 2007·Zeitschrift für Rheumatologie·J Richter, C Iking-Konert
Mar 5, 2013·Zeitschrift für Rheumatologie·A D Keck, U A Walker
Jul 4, 2012·Journal of Neurology·Joerg-Patrick Stübgen
Jun 23, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Cristina SancriccaMassimiliano Mirabella
Mar 12, 2005·Current Rheumatology Reports·Ann M Reed, Thomas Mason
Apr 29, 2010·Current Rheumatology Reports·Adam M Huber
May 2, 2007·Nature Clinical Practice. Rheumatology·Ingrid E Lundberg, Helene Alexanderson
May 17, 2011·Rheumatology·Elien A M MahlerMadelon C Vonk
Apr 4, 2006·Current Opinion in Rheumatology·Alan N Baer
Jun 1, 2005·Journal of Clinical Neuromuscular Disease·Mark B Bromberg
Apr 3, 2009·Current Opinion in Rheumatology·Helene Alexanderson
Sep 20, 2011·Current Opinion in Rheumatology·Heřman F Mann, Jiří Vencovský
Dec 23, 2011·Current Opinion in Rheumatology·Helene Alexanderson, Ingrid E Lundberg
Aug 5, 2008·Nuclear Medicine Communications·Olivier A HarariAli Jawad
Sep 29, 2011·Pediatric Rheumatology Online Journal·Erkan DemirkayaUNKNOWN FMF Arthritis Vasculitis and Orphan Disease Research in Paediatric Rheumatology (FAVOR)
Jan 8, 2014·Medicina clínica·Albert Selva-O'CallaghanJosep M Grau Junyent
Aug 12, 2006·Current Rheumatology Reports·Lauren M Pachman, Adele L Boskey
May 8, 2008·Current Rheumatology Reports·Nicolino RupertoAlberto Martini
Apr 3, 2012·Current Rheumatology Reports·Helene Alexanderson
Dec 29, 2015·Expert Review of Clinical Pharmacology·Serena FasanoDavid A Isenberg
Jun 14, 2006·Autoimmunity·Angelo RavelliAlberto Martini
Feb 9, 2016·Journal of Internal Medicine·H Alexanderson
Nov 5, 2013·Rheumatic Diseases Clinics of North America·Lisa G RiderOlcay Y Jones
Mar 23, 2011·Seminars in Arthritis and Rheumatism·Raj NairDinesh Khanna
Dec 9, 2009·Archives of Physical Medicine and Rehabilitation·Jilda N Vargus-Adams, Lauren K Martin
Oct 27, 2009·Best Practice & Research. Clinical Rheumatology·Hermine I Brunner, Angelo Ravelli
Oct 27, 2009·Best Practice & Research. Clinical Rheumatology·Lucy R Wedderburn, Lisa G Rider
Nov 1, 2009·Reumatología clinica·Lilia Andrade-Ortega
Nov 1, 2008·Arthritis and Rheumatism·Shabina M SultanDavid A Isenberg
Jul 1, 2011·Arthritis Care & Research·Carol A WallaceUNKNOWN Paediatric Rheumatology International Trials Organisation
Jun 21, 2011·Annals of Neurology·UNKNOWN Muscle Study Group

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.