International Council for Standardization in Haematology (ICSH) recommendations for laboratory measurement of ADAMTS13.

International Journal of Laboratory Hematology
I J MackieRoss Baker

Abstract

This guidance document was prepared on behalf of the International Council for Standardization in Haematology (ICSH), by the ADAMTS13 Assay Working Group, which comprises an international group of both clinical and laboratory experts. The document provides recommendations on best practice for the performance of ADAMTS13 assays in clinical laboratories. ADAMTS13 assays support the differential diagnosis of thrombotic microangiopathies and have utility in the management of thrombotic thrombocytopenic purpura (TTP). There are three types of assay: activity, antigen and autoantibody/inhibitor assays. Methods for activity assays differ in terms of sensitivity, specificity, precision and turnaround time. The most widely used assays involve VWF peptide substrates and either chromogenic ELISA or FRET techniques, although chemiluminescence assays and rapid screening tests have recently become available. Tests for autoantibodies and inhibitors allow confirmation of acquired, immune-mediated TTP, while antigen assays may be useful in congenital TTP and as prognostic markers. In this document, we have attempted to describe ADAMTS13 assays and the conditions that affect them, as well as: blood collection, sample processing, quality control,...Continue Reading

References

Nov 26, 1998·The New England Journal of Medicine·H M Tsai, E C Lian
Apr 2, 2005·British Journal of Haematology·Koichi KokameToshiyuki Miyata
Feb 8, 2006·Journal of Thrombosis and Haemostasis : JTH·E GrootR Fijnheer
May 13, 2006·Journal of Thrombosis and Haemostasis : JTH·J A Kremer HovingaB Lämmle
Apr 10, 2008·British Journal of Haematology·Ming JinHaifeng M Wu
Feb 18, 2009·International Journal of Laboratory Hematology·G LippiE J Favaloro
Jan 22, 2010·Journal of Thrombosis and Haemostasis : JTH·F PeyvandiS J Machin
Nov 26, 2010·Thrombosis and Haemostasis·Roberta PallaFlora Peyvandi
Nov 16, 2011·International Journal of Laboratory Hematology·G ZiniUNKNOWN International Council for Standardization in Haematology (ICSH)
Apr 18, 2012·Journal of Thrombosis and Haemostasis : JTH·I ManciniF Peyvandi
May 26, 2012·British Journal of Haematology·Marie ScullyUNKNOWN British Committee for Standards in Haematology
Jan 12, 2013·Thrombosis and Haemostasis·Ian MackieFlora Peyvandi
Jun 7, 2013·The New England Journal of Medicine·C M LegendreC Loirat
Jul 13, 2013·Thrombosis and Haemostasis·Sandrine ThouzeauAgnès Veyradier
Sep 30, 2014·Thrombosis Research·Bérangère JolyAgnès Veyradier
Dec 17, 2014·Proceedings of the National Academy of Sciences of the United States of America·Kieron SouthDavid A Lane
Dec 17, 2014·Proceedings of the National Academy of Sciences of the United States of America·Joshua MuiaJ Evan Sadler
Feb 26, 2015·Journal of Thrombosis and Haemostasis : JTH·A R HubbardUNKNOWN Subcommittee on von Willebrand Factor
Mar 18, 2015·Journal of Thrombosis and Haemostasis : JTH·R-N LuX L Zheng
Aug 22, 2015·Bioanalysis·Mark A Marzinke, William Clarke
Feb 11, 2016·The New England Journal of Medicine·Flora PeyvandiUNKNOWN TITAN Investigators

❮ Previous
Next ❯

Citations

Apr 10, 2021·The Journal of Pediatrics·Francesca MinoiaUNKNOWN MAS/sJIA Working Group of the Pediatric Rheumatology European Society (PReS)
May 16, 2021·American Journal of Hematology·Emmanuel J FavaloroGiuseppe Lippi
Jul 20, 2021·Expert Review of Hematology·Inés Gómez-SeguíJavier de la Rubia Comos
Aug 26, 2021·International Journal of Laboratory Hematology·Gina ZiniUNKNOWN International Council for Standardization in Hematology (ICSH)

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.