International study on the comparability of Apo A-1 and Apo B methods

Clinica Chimica Acta; International Journal of Clinical Chemistry
D GrafnetterL Lonsky

Abstract

Apo A-1 and Apo B levels have become increasingly important as a mean of assessing risk and susceptibility to cardiovascular diseases. These proteins are measured routinely in numerous clinical and research laboratories due primarily to the ability to mechanise the immunological assay method and to the ready availability of commercially produced antisera and standards which are often sold in kit form. However, if these variables are to be used to assess the clinical risk of disease reliably, the test methods should have a low degree of imprecision and inaccuracy, to reduce false positive and negative results. The 'normal' and 'pathological' ranges for both proteins also need to be clearly defined. In order to be able to define clinical ranges and establish quality control limits on both a national and international level the inaccuracy and imprecision of the different methods used to assay the parameters need to be established. Since the technical expertise and the equipment and reagents used vary between laboratories, and because there is no internationally recognized calibration material, a survey conducted to establish imprecision and inaccuracy must include many laboratories to take these variations into account. At the WHO...Continue Reading

References

Mar 1, 1984·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·J D BrunzellP O Kwiterovich
Apr 1, 1982·Atherosclerosis·G De BackerJ P Deslypere
Sep 1, 1981·Analytical Biochemistry·M RosseneuF Belpaire

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Citations

Sep 1, 1993·European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies·A B Sigalov
Dec 1, 1994·European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies·G J BoermaA van Teunenbroek

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