International subarachnoid aneurysm trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised comparison of effects on survival, dependency, seizures, rebleeding, subgroups, and aneurysm occlusion

Andrew J MolyneuxInternational Subarachnoid Aneurysm Trial (ISAT) Collaborative Group


Two types of treatment are being used for patients with ruptured intracranial aneurysms: endovascular detachable-coil treatment or craniotomy and clipping. We undertook a randomised, multicentre trial to compare these treatments in patients who were suitable for either treatment because the relative safety and efficacy of these approaches had not been established. Here we present clinical outcomes 1 year after treatment. 2143 patients with ruptured intracranial aneurysms, who were admitted to 42 neurosurgical centres, mainly in the UK and Europe, took part in the trial. They were randomly assigned to neurosurgical clipping (n=1070) or endovascular coiling (n=1073). The primary outcome was death or dependence at 1 year (defined by a modified Rankin scale of 3-6). Secondary outcomes included rebleeding from the treated aneurysm and risk of seizures. Long-term follow up continues. Analysis was in accordance with the randomised treatment. We report the 1-year outcomes for 1063 of 1073 patients allocated to endovascular treatment, and 1055 of 1070 patients allocated to neurosurgical treatment. 250 (23.5%) of 1063 patients allocated to endovascular treatment were dead or dependent at 1 year, compared with 326 (30.9%) of 1055 patients...Continue Reading


Jul 16, 1987·The New England Journal of Medicine·B Freedman
Dec 12, 2001·Stroke; a Journal of Cerebral Circulation·A RonkainenM Vapalahti
Mar 7, 2003·Lancet·Robert E HarbaughMark N Hadley
May 15, 2003·Journal of Neurosurgery·Yuichi MurayamaFernando Viñuela
May 31, 2003·Stroke; a Journal of Cerebral Circulation·Jean RaymondDaniel Roy
Jul 18, 2003·Lancet·David O WiebersUNKNOWN International Study of Unruptured Intracranial Aneurysms Investigators
Jan 14, 2005·The New England Journal of Medicine·Michael M ToddUNKNOWN Intraoperative Hypothermia for Aneurysm Surgery Trial (IHAST) Investigators
Nov 12, 2005·Clinical Trials : Journal of the Society for Clinical Trials·Richard B ScottKatherine Carpenter

❮ Previous
Next ❯


Sep 8, 2012·Der Anaesthesist·P KellnerC Raspé
Aug 31, 2013·Der Anaesthesist·A Berlis
Aug 10, 2006·Der Nervenarzt·M Forsting, I Wanke
Feb 18, 2011·Der Radiologe·A Zimmer, W Reith
Jun 2, 2007·Intensive Care Medicine·Guiseppe CiterioNino Stocchetti
Jun 18, 2009·Intensive Care Medicine·Robert D StevensPeter J Andrews
Nov 10, 2006·Neuroradiology·Iris Q GrunwaldWolfgang Reith
Nov 23, 2006·Neuroradiology·Noel F FanningJohn Thornton
Feb 24, 2007·Neuroradiology·Joon K SongAlejandro Berenstein
Nov 13, 2007·Neuroradiology·Byung Moon KimYu Sam Won
Sep 23, 2008·Neuroradiology·Jan GrallaWilhem Kuker
Sep 23, 2008·Neuroradiology·Isabel Wanke, Michael Forsting
Apr 15, 2010·Neuroradiology·Joonho ChungYong Sam Shin
Apr 27, 2013·Neuroradiology·Anne J SchmittMonika Killer-Oberpfalzer
Jul 19, 2013·Neuroradiology·Olli I TähtinenLeo Keski-Nisula
May 30, 2007·Cardiovascular and Interventional Radiology·C P ShorttM J Lee
Jun 28, 2012·Cardiovascular and Interventional Radiology·Georg MühlenbruchMartin Wiesmann
Feb 15, 2011·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Maria VarelaGeorge A Alexiou
Dec 15, 2011·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Bartley MitchellMichel Mawad
Mar 22, 2008·Journal of Neurology·José M FerroR Peralta
Apr 25, 2012·Journal of Neurology·Christian FungThomas Nyffeler
Oct 4, 2008·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Gian Piero TonnarelliPaolo Roccucci
Mar 23, 2010·Annals of Biomedical Engineering·M Haithem BabikerDavid H Frakes
Nov 22, 2011·Annals of Biomedical Engineering·Jennifer N RodriguezDuncan J Maitland

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cajal Bodies & Gems

Cajal bodies or coiled bodies are dense foci of coilin protein. Gemini of Cajal bodies, or gems, are microscopically similar to Cajal bodies. It is believed that Cajal bodies play important roles in RNA processing while gems assist the Cajal bodies. Find the latest research on Cajal bodies and gems here.


Aneurysms are outward distensions or bulges that occurs in a weakened wall of blood vessels. Discover the latest research on aneurysms here.