International Union of Basic and Clinical Pharmacology. CIX. Differences and Similarities between Human and Rodent Prostaglandin E2 Receptors (EP1-4) and Prostacyclin Receptor (IP): Specific Roles in Pathophysiologic Conditions.

Pharmacological Reviews
Xavier NorelLucie H Clapp

Abstract

Prostaglandins are derived from arachidonic acid metabolism through cyclooxygenase activities. Among prostaglandins (PGs), prostacyclin (PGI2) and PGE2 are strongly involved in the regulation of homeostasis and main physiologic functions. In addition, the synthesis of these two prostaglandins is significantly increased during inflammation. PGI2 and PGE2 exert their biologic actions by binding to their respective receptors, namely prostacyclin receptor (IP) and prostaglandin E2 receptor (EP) 1-4, which belong to the family of G-protein-coupled receptors. IP and EP1-4 receptors are widely distributed in the body and thus play various physiologic and pathophysiologic roles. In this review, we discuss the recent advances in studies using pharmacological approaches, genetically modified animals, and genome-wide association studies regarding the roles of IP and EP1-4 receptors in the immune, cardiovascular, nervous, gastrointestinal, respiratory, genitourinary, and musculoskeletal systems. In particular, we highlight similarities and differences between human and rodents in terms of the specific roles of IP and EP1-4 receptors and their downstream signaling pathways, functions, and activities for each biologic system. We also highlig...Continue Reading

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Aug 22, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Pu WangZhan-You Wang
Oct 1, 2013·The Journal of Allergy and Clinical Immunology·Zbigniew ZasłonaMarc Peters-Golden
Oct 4, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jenny U JohanssonKatrin I Andreasson
Oct 18, 2013·Journal of Lipid Research·Mercedes CamachoL Vila
Nov 15, 2013·The Tohoku Journal of Experimental Medicine·Siti Safiah MokhtarAida Hanum Ghulam Rasool
Nov 19, 2013·Pharmaceutical Patent Analyst·Jessica K NorbergEmmanuelle J Meuillet
Dec 7, 2013·Free Radical Biology & Medicine·Edna Aparecida SilveiraD V Vassallo
Dec 27, 2013·Expert Opinion on Pharmacotherapy·Vishwanath Hanchanale, Ian Eardley
Jan 18, 2014·Biochemical Pharmacology·Eiron CudabackC Dirk Keene
Jan 29, 2014·American Journal of Respiratory and Critical Care Medicine·Joshua M DiamondLung Transplant Outcomes Group
Jan 31, 2014·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Stefano VendrameDorothy Klimis-Zacas
Feb 5, 2014·The Journal of Biological Chemistry·Jacob KachNickolai O Dulin
Mar 13, 2014·American Journal of Respiratory and Critical Care Medicine·Robert S StearmanMark Geraci
Apr 24, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bo WeiXinmin Liu
May 9, 2014·The Journal of Clinical Investigation·David M KoflerDavid A Hafler
Aug 16, 2014·Reproduction, Fertility, and Development·Mariana RiosManuel Villalón
Aug 27, 2014·Clinical and Experimental Medicine·Ming-Kai TsaiChih-Hsing Hung
Sep 15, 2014·Molecular Neurobiology·Chun-Hsien ChuJau-Shyong Hong
Oct 7, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Careesa C LiuMarc D Grynpas
Nov 16, 2014·Current Treatment Options in Cardiovascular Medicine·Prachi MehndirattaBradford B Worrall
Nov 22, 2014·Stroke; a Journal of Cerebral Circulation·Rune RasmussenNiels Vidiendal Olsen
Dec 2, 2014·International Journal of Oncology·Yoshinori MinamiYoshinobu Ohsaki
Dec 3, 2014·Neurotoxicology·Shekher MohanSylvain Doré
Dec 17, 2014·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Carolin NoackPeter Dieter
Dec 19, 2014·Journal of Gastroenterology and Hepatology·Kikuko AmagaseKoji Takeuchi
Jan 27, 2015·Prostaglandins & Other Lipid Mediators·Stephanie M KnebelAlan H Stephenson
Feb 11, 2015·The Journal of Clinical Investigation·Ankang LuYing Yu
Mar 6, 2015·The Journal of Pharmacology and Experimental Therapeutics·Hitoshi KashiwagiFumitaka Ushikubi
Mar 22, 2015·The Journal of Biological Chemistry·Rieko MuramatsuToshihide Yamashita
Apr 29, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Milena SokolowskaJames H Shelhamer
May 13, 2015·The Journal of Allergy and Clinical Immunology·Jesper SäfholmMikael Adner
Jul 23, 2015·Proceedings of the National Academy of Sciences of the United States of America·Joe A AroshSakhila K Banu
Jul 24, 2015·Chest·Zbigniew Zaslona, Marc Peters-Golden
Sep 4, 2015·Molecular Neurobiology·Tatsurou YagamiYasuhiro Yamamoto
Sep 29, 2015·Mediators of Inflammation·Quanxing ShiShouli Wang
Sep 30, 2015·American Journal of Respiratory and Critical Care Medicine·Racquel Domingo-GonzalezB B Moore
Oct 16, 2015·Prostaglandins & Other Lipid Mediators·Marie-Anne MawhinJean-Etienne Fabre
Oct 21, 2015·Endocrinology·Ryan P CeddiaRichard M Breyer
Oct 28, 2015·British Journal of Pharmacology·Kyosuke ShishikuraHisanori Horiuchi
Nov 27, 2015·Journal of Applied Physiology·Sophia Z LiuTodd A Trappe
Nov 28, 2015·Rheumatic Diseases Clinics of North America·Xena Whittier, Kenneth G Saag
Feb 10, 2016·British Journal of Pharmacology·María S AvendañoAna M Briones
Mar 5, 2016·Journal of Leukocyte Biology·Christina DraijerBarbro N Melgert
Mar 5, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Pei-Chi ChanPo Shiuan Hsieh
Mar 17, 2016·ACS Chemical Neuroscience·Nathaniel S Woodling, Katrin I Andreasson
Mar 24, 2016·Journal of the American Society of Nephrology : JASN·Fei WangTianxin Yang
Apr 17, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Jenna L LeclercSylvain Doré
Apr 25, 2016·Best Practice & Research. Clinical Rheumatology·Hilde BrouwersAndreea Ioan-Facsinay
Jun 19, 2016·British Journal of Clinical Pharmacology·Carlo Patrono
Jul 28, 2016·Advances in Pharmacology·O Baretella, Paul M Vanhoutte