International validation of the prognostic value of lymphovascular invasion in patients treated with radical cystectomy

BJU International
Shahrokh F ShariatYves Fradet

Abstract

To externally validate the prognostic value of lymphovascular invasion (LVI) in a large international cohort of patients treated with radical cystectomy (RC) for urothelial carcinoma of the bladder (UCB). We collected data from 4257 patients treated with RC and pelvic lymphadenectomy for UCB, without neoadjuvant chemotherapy, at 12 centres. LVI was defined as presence of nests of tumour cells within an endothelium-lined space. LVI was detected in 1407 patients (33.1%); the proportion of LVI increased with advancing stage, higher grade, soft-tissue surgical margin involvement, and lymph node metastasis (P < 0.001 for all). In standard multivariate models, LVI was associated with both disease recurrence (hazard ratio 1.43, P < 0.001) and cancer-specific mortality (1.45, P < 0.001). In the entire cohort, adding LVI to a base model that included standard features improved only minimally its predictive accuracy for both recurrence and cancer-specific mortality (by 1.1% and 1.2%, respectively). In 3122 patients with negative lymph nodes, LVI remained independently associated with and improved the predictive accuracy of the standard predictors for recurrence (hazard ratio 1.68, P < 0.001; +2.3%) and cancer-specific mortality (1.70, P ...Continue Reading

References

Jan 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·I A SesterhennN J Vogelzang
May 14, 1982·JAMA : the Journal of the American Medical Association·F E HarrellR A Rosati
Mar 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jean-Nicolas VautheyDavid M Nagorney
Apr 27, 2002·Science·Timothy P PaderaRakesh K Jain
Apr 17, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Peter AlbersUNKNOWN German Testicular Cancer Study Group
Dec 18, 2004·Cancer Research·Kari AlitaloErkki Ruoslahti
Jun 11, 2005·The Journal of Urology·Marcus L QuekDonald G Skinner
Aug 24, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Yair LotanArthur I Sagalowsky
Nov 11, 2005·The Journal of Urology·Liang ChengMichael O Koch
Jan 10, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Andres A RomaMing Zhou
Mar 3, 2006·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Jiro HaradaKeiichi Fukuyama
Aug 15, 2006·Current Opinion in Urology·Ferran Algaba
Dec 20, 2007·Current Opinion in Urology·Shahrokh F ShariatSeth P Lerner

❮ Previous
Next ❯

Citations

Sep 10, 2010·Der Urologe. Ausg. A·C-H Ohlmann, M Stöckle
Sep 1, 2011·Der Urologe. Ausg. A·J KamradtM Stöckle
Apr 19, 2011·World Journal of Urology·Thomas F ChromeckiShahrokh F Shariat
Jun 18, 2011·World Journal of Urology·Grégory VerhoestKarim Bensalah
Dec 7, 2010·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·C PfisterUNKNOWN Oncology Committee of the French Association of Urology (CCAFU)
Sep 10, 2011·Advances in Urology·Ehab A Elzayat, Ali A Al-Zahrani
Oct 27, 2012·Annals of Surgical Oncology·Evanguelos XylinasShahrokh F Shariat
Nov 8, 2013·Der Urologe. Ausg. A·C-H Ohlmann, M De Santis
Apr 2, 2013·The Urologic Clinics of North America·Siamak Daneshmand
Jan 2, 2013·Clinical Genitourinary Cancer·Julien BranchereauJérôme Rigaud
Oct 16, 2012·The Journal of Urology·Christian BolenzStefan W Schneider
Nov 8, 2011·Urologic Oncology·Yair LotanUNKNOWN Bladder Cancer Advocacy Network
Apr 19, 2011·The Journal of Urology·In Gab JeongChoung-Soo Kim
Feb 22, 2011·The Journal of Urology·Guru SonpavdeShahrokh F Shariat
Jan 25, 2011·The Journal of Urology·Ramy F YoussefYair Lotan
Nov 26, 2010·The Mount Sinai Journal of Medicine, New York·Matthew D Galsky, Simon J Hall
Nov 6, 2010·BJU International·David S YeeJames A Eastham
Jun 26, 2012·BJU International·Thomas F ChromeckiShahrokh F Shariat
Sep 4, 2012·BJU International·Michael RinkUNKNOWN Bladder Cancer Research Consortium
Sep 10, 2014·International Journal of Urology : Official Journal of the Japanese Urological Association·David M BermanChristopher M Booth
Nov 21, 2014·ANZ Journal of Surgery·Nariman AhmadiManish I Patel
Jul 22, 2014·International Journal of Urology : Official Journal of the Japanese Urological Association·Taekmin KwonChoung-Soo Kim
Jan 18, 2015·World Journal of Urology·Georgios GakisArnulf Stenzl

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.