International veterinary epilepsy task force recommendations for systematic sampling and processing of brains from epileptic dogs and cats

BMC Veterinary Research
Kaspar MatiasekHolger A Volk

Abstract

Traditionally, histological investigations of the epileptic brain are required to identify epileptogenic brain lesions, to evaluate the impact of seizure activity, to search for mechanisms of drug-resistance and to look for comorbidities. For many instances, however, neuropathological studies fail to add substantial data on patients with complete clinical work-up. This may be due to sparse training in epilepsy pathology and or due to lack of neuropathological guidelines for companion animals.The protocols introduced herein shall facilitate systematic sampling and processing of epileptic brains and therefore increase the efficacy, reliability and reproducibility of morphological studies in animals suffering from seizures.Brain dissection protocols of two neuropathological centres with research focus in epilepsy have been optimised with regards to their diagnostic yield and accuracy, their practicability and their feasibility concerning clinical research requirements.The recommended guidelines allow for easy, standardised and ubiquitous collection of brain regions, relevant for seizure generation. Tissues harvested the prescribed way will increase the diagnostic efficacy and provide reliable material for scientific investigations.

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Citations

Apr 17, 2016·The Veterinary Record·Holger A Volk
Sep 5, 2018·Journal of the American Veterinary Medical Association·Lorenzo MariLuisa De Risio
Feb 23, 2017·Proceedings of the National Academy of Sciences of the United States of America·Franziska WielaenderHannes Lohi
May 24, 2019·Toxicologic Pathology·Jessica S FortinBrad Bolon
Mar 19, 2021·Journal of Veterinary Internal Medicine·Pia R QuittAndrea Fischer
Aug 7, 2021·Life·Thilo von KlopmannClare Rusbridge

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Methods Mentioned

BETA
pharmacotherapy
biopsies
dissection

Software Mentioned

CNS

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