PMID: 8581551Nov 1, 1995Paper

Internet-based support for bioscience research: a collaborative genome center for human chromosome 12

Journal of the American Medical Informatics Association : JAMIA
P L MillerR Kucherlapati

Abstract

This paper describes an approach that provides Internet-based support for a genome center to map human chromosome 12, as a collaboration between laboratories at the Albert Einstein College of Medicine in Bronx, New York, and the Yale University School of Medicine in New Haven, Connecticut. Informatics is well established as an important enabling technology within the genome mapping community. The goal of this paper is to use the chromosome 12 project as a case study to introduce a medical informatics audience to certain issues involved in genome informatics and in the Internet-based support of collaborative bioscience research. Central to the approach described is a shared database (DB/12) with Macintosh clients in the participating laboratories running the 4th Dimension database program as a user-friendly front end, and a Sun SPARCstation-2 server running Sybase. The central component of the database stores information about yeast artificial chromosomes (YACs), each containing a segment of human DNA from chromosome 12 to which genome markers have been mapped, such that an overlapping set of YACs (called a "contig") can be identified, along with an ordering of the markers. The approach also includes 1) a map assembly tool devel...Continue Reading

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Citations

Sep 1, 1996·Mammalian Genome : Official Journal of the International Mammalian Genome Society·J M JonesM H Meisler
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Jun 16, 2011·Journal of the American Medical Informatics Association : JAMIA·Atul J Butte, Nigam H Shah
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Oct 1, 1996·Journal of Medical Genetics·T DrumhellerD I Smith
Sep 14, 2000·Journal of the American Medical Informatics Association : JAMIA·P L Miller

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