PMID: 8589642Nov 1, 1995Paper

Internucleosomal DNA cleavage in HeLa cells exposed to cisplatin

Biochemistry and Molecular Biology International
V MaldonadoA Ortega

Abstract

Exposure of HeLa cells to Cisplatin resulted in cell death characteristic of a suicide process known as apoptosis, as stated by morphologic features, extensive and specific DNA fragmentation and in situ end labeling of DNA breaks. The apoptotic cell death was induced timely in a dose-dependent manner, without any primary necrosis at the concentrations used. In contrast to other reports, the death in this cell line was accompanied by low-molecular weight DNA fragmentation. These results and their relevance to the apoptotic process are discussed.

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis