PMID: 8601651Apr 1, 1996Paper

Interobserver concordance in discriminating clinical atypia of melanocytic nevi, and correlations with histologic atypia

Journal of the American Academy of Dermatology
L J MeyerM H Skolnick

Abstract

The clinical features attributed to atypical (formerly ¿dysplastic") nevi and to the atypical multiple mole melanoma syndrome have been used in clinical practice, as well as experimentally, to assign melanoma risk. Little information is available, however, on the interobserver reliability in assessing those features. Our purposes were to quantify interobserver and intraobserver concordances in recognizing certain atypical characteristics of nevi and to correlate the clinical assessments with the histologic characteristics. Three observers evaluated clinical photographs of 100 pigmented lesions (predominantly melanocytic nevi, with some lentigines and seborrheic keratoses) from 95 subjects, of whom 85 were family members of four multiple melanoma kindreds and 10 were spouses. Each lesion was rated for border irregularity, color variegation, surface contour irregularity, pigment diffusion, and macularity versus papularity. Predictions were made as to the histologic diagnoses and presence of melanocytic atypia for those lesions judged to be nevi. The pair-wise concordances before agreement on specific criteria were quantified by kappa statistics, which indicated slight to fair agreement in judging the atypical clinical characteris...Continue Reading

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Citations

Dec 9, 1997·Journal of Clinical Pathology·W J Mooi
Jul 19, 2013·PloS One·Philipp TschandlHarald Kittler
Oct 1, 2013·Dermatologic Clinics·Harald Kittler, Philipp Tschandl
Jun 19, 2012·Journal of the American Academy of Dermatology·Keith Duffy, Douglas Grossman
May 8, 2007·Journal of the American Academy of Dermatology·Jared JagdeoUNKNOWN Department of Veteran Affairs Topical Tretinoin Chemoprevention Trial Group
Nov 28, 2013·Journal of Cutaneous Pathology·Timothy H McCalmont
Nov 2, 2013·Journal of the American Academy of Dermatology·Michael W PiepkornJoann G Elmore
Nov 6, 2008·Journal of Cutaneous Pathology·Michael S Rabkin
Jan 22, 2008·The British Journal of Dermatology·J B LipoffA C Halpern
Oct 4, 2016·Journal of the American Academy of Dermatology·Kachiu C LeeJoann G Elmore
Mar 29, 2002·The Journal of Pathology·Lieve BrochezJean-Marie Naeyaert
Feb 1, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·David E Elder
Jul 16, 2008·Melanoma Research·Suhan GunastiVarol Lutfu Aksungur
Oct 4, 2018·Cognitive Research: Principles and Implications·Brett D RoadsJames W Tanaka
Feb 6, 2020·Cognitive Research: Principles and Implications·Li Z ShaYuhong V Jiang

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