Interobserver reliability in the histopathological diagnosis of cartilaginous tumors in patients with multiple osteochondromas.

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Carlos E de AndreaJ V Bovée

Abstract

The distinction between benign and malignant cartilaginous tumors located peripherally in the bone may be a challenging task in surgical pathology. The aim of this study was to investigate interobserver reliability in histological diagnosis of cartilaginous tumors in the setting of multiple osteochondromas and to evaluate possible histological parameters that could differentiate among osteochondroma, low- and high-grade secondary peripheral chondrosarcoma. Interobserver reliability was assessed by 12 specialized bone-tumor pathologists in a set of 38 cases. Substantial agreement on diagnosis among all the reviewers was observed (intraclass correlation coefficient=0.78). Our study confirmed that mitotic figures and nuclear pleomorphism are hallmarks of high-grade secondary peripheral chondrosarcoma. However, despite the substantial agreement, we demonstrated that histology alone cannot distinguish osteochondroma from low-grade secondary peripheral chondrosarcoma in the setting of multiple osteochondromas, as nodularity, the presence of binucleated cells, irregular calcification, cystic/mucoid changes and necrosis were not helpful to indicate malignant transformation of an osteochondroma. On the other hand, among the concordant c...Continue Reading

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Citations

Jan 25, 2016·The Journal of Hand Surgery·Juan González Del PinoJesse B Jupiter
Jul 1, 2014·ANZ Journal of Surgery·Russell W JamiesonDavid R Lewis
Dec 27, 2019·Archives of Pathology & Laboratory Medicine·David SusterG Petur Nielsen
Jan 23, 2021·Advances in Anatomic Pathology·Joon Hyuk Choi, Jae Y Ro

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