Interobserver variability in the pathological assessment of malignant colorectal polyps

The British Journal of Surgery
K KomutaR Madoff

Abstract

Treatment of patients with malignant large bowel polyps is highly dependent on pathological evaluation. The aim of this study was to evaluate interobserver variability in the pathological assessment of endoscopically removed polyps. The records of 88 patients with colorectal cancer who underwent endoscopic removal of malignant polyps were reviewed. Study investigators reviewed the initial pathology report; three experienced gastrointestinal pathologists reviewed all slides in a blinded fashion. Interobserver variability of pathological assessment of malignant polyps was analysed by kappa statistics. Seventy-six (86 per cent) of the 88 patients had malignant polyps and 12 (14 per cent) had carcinoma in situ. Agreement between experienced pathologists was substantial with regard to T stage (kappa = 0.725), resection margin status (kappa = 0.668) and Haggitt's classification (kappa = 0.682), but comparison of initial and experienced pathologists' assessment demonstrated only moderate agreement in these areas (kappa = 0.516, kappa = 0.555 and kappa = 0.578 respectively). Agreement between even experienced pathologists was poor with respect to histological grade of differentiated adenocarcinomas (kappa = 0.163) and angiolymphatic ve...Continue Reading

References

Jan 1, 1978·Diseases of the Colon and Rectum·S Nivatvongs, S M Goldberg
Oct 1, 1975·Annals of Surgery·W I Wolff, H Shinya
Oct 1, 1992·Diseases of the Colon and Rectum·C W PollardR R Dozois
Apr 11, 1991·Diseases of the Colon and Rectum·S NivatvongsL F Jacques
Jun 1, 1987·Annals of Surgery·W O RichardsS Littauer
Nov 1, 1985·The British Journal of Surgery·N S WilliamsC C Bird
Jan 1, 1973·Journal of Clinical Pathology·T MutoB C Morson
Oct 1, 1983·The American Journal of Surgical Pathology·H S Cooper
Jan 1, 1984·Diseases of the Colon and Rectum·J C LangerJ B Cullen
Aug 1, 1984·The British Journal of Surgery·R K PhillipsL P Fielding
Apr 1, 1983·Journal of Clinical Pathology·G D ThomasN S Williams
Dec 1, 1995·Diseases of the Colon and Rectum·R KikuchiY Uchida
Jan 1, 2003·The Surgical Clinics of North America·Santhat Nivatvongs
Sep 1, 1958·British Journal of Cancer·C E DUKES, H J BUSSEY

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Citations

Mar 26, 2008·Surgical Endoscopy·Peter J Mitchell, Najib Y Haboubi
Aug 1, 2005·Clinics in Colon and Rectal Surgery·James M Church
Oct 14, 2011·Surgical Endoscopy·Pascal G DoorneboschHans Morreau
Jan 4, 2006·Surgical Oncology Clinics of North America·Josh Kehoe, Vijay P Khatri
Nov 23, 2006·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·C HassanS Morini
Jul 17, 2013·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·J G WilliamsUNKNOWN Association of Coloproctology of Great Britain and Ireland
Sep 12, 2016·Medical Image Analysis·Korsuk SirinukunwattanaNasir M Rajpoot
Aug 22, 2009·European Journal of Gastroenterology & Hepatology·Bernard DenisJean François Fléjou
Apr 18, 2019·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·A C CurrieR H Kennedy
Oct 1, 2013·Scandinavian Journal of Gastroenterology·Luca Reggiani-BonettiMaurizio Ponz de Leon
Aug 21, 2019·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Dhruv LoweGary Brooks
Jan 21, 2010·Diseases of the Colon and Rectum·Cesare HassanBruno Buongiorno Nardelli
Jan 9, 2020·Diseases of the Colon and Rectum·Tamara I GimonAnthony MacLean
Dec 17, 2014·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·R ZinicolaR Fiocca
Jan 27, 2015·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·L M WangN Mortensen
Oct 8, 2016·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Yara BackesMiangela M Lacle

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