PMID: 45498Jul 1, 1979

Interoceptive conditioning through repeated suppression of morphine-abstinence. II. Relapse-testing

The Pavlovian Journal of Biological Science
D B MillerA Wikler


The reinforcing properties of etonitazene, both conditioned and unconditioned, were measured in rats that had received saline only by continuous intravenous infusion ("saline" group) and in two groups of rats that had been physically dependent on morphine to equal degrees (and presumably had developed equal degrees of tolerance to morphine): one by once daily passive intravenous injection of morphine ("injection" group) and the other by passive continuous intravenous morphine infusion at the same daily doses for approximately the same number of days ("infusion" group). Prior to passive saline and morphine administration, all rats were trained to press right- and left-sided levers for water reinforcement from 1600 to 0800 hrs to a not more than 60-40 split, and these and other measures ("baselines") were repeated after recovery from the early (acute) morphine-abstinence syndromes. Then etonitazene, 5 micrograms/ml, was substituted for water on the nonpreferred side and all measures were repeated from 1600 to 0800 hrs once every two weeks for 20 weeks (10 "relapse" tests). It was postulated that the daily cycles of morphine-abstinence and suppression of abstinence in the injection group only would generate latent interoceptively ...Continue Reading


Jun 9, 2020·Frontiers in Behavioral Neuroscience·Greer McKendrickNicholas M Graziane

Related Concepts

Reaction Time
Morphine Abuse
Intravenous Injections
Morphine Measurement
August Rats
Withdrawal Symptoms
Psychological Reinforcement
Visual Suppression
Self Administration

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