Interoceptive processing deficit: A behavioral marker for subtyping Parkinson's disease

Parkinsonism & Related Disorders
Gabriella SantangeloMassimiliano Conson

Abstract

Non-motor symptoms in Parkinson's disease (PD), such as cognitive, emotional, autonomic and somatosensory alterations, are not ubiquitous but vary between the tremor dominant (TD) and postural instability/gait difficulty (PIGD) subtypes of the syndrome. Non-motor phenomena (e.g., anxiety, depression and apathy) have been related to representation of autonomic and somatosensory sensations (interoception), and recent findings suggest interoceptive deficits in PD. To test whether interoceptive processing is differently affected in TD and PIGD phenotypes, by assessing both interoceptive accuracy and sensibility in PD patients with TD and PIGD subtypes, and in healthy controls. Interoceptive accuracy was measured by the heartbeat perception task requiring participants to count their own heartbeats in a given time interval. A time-estimation, control task was also administered asking participants to count the seconds in a set period of time. Interoceptive sensibility was assessed by a questionnaire of subjective interoception. Finally, the patients underwent measures of anxiety, depression, apathy and anhedonia, and impulsive-compulsive disturbances. The main results showed reduced interoceptive accuracy and sensibility in TD patient...Continue Reading

Citations

May 9, 2019·Annual Review of Clinical Psychology·Martin P PaulusSahib S Khalsa
Dec 1, 2020·European Eating Disorders Review : the Journal of the Eating Disorders Association·Felicitas WeineckOlga Pollatos
Jan 7, 2021·Experimental Brain Research·Chiara BaianoMassimiliano Conson
Jan 31, 2020·Neuroscience and Biobehavioral Reviews·Paul FrewenGeorg Northoff
Dec 31, 2020·Trends in Neurosciences·Bruno BonazHugo D Critchley
Aug 18, 2021·Neuroscience and Biobehavioral Reviews·Chiara BaianoLouise P Kirsch

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