PMID: 6401931Feb 1, 1983Paper

Interorgan metabolism of amino acids in streptozotocin-diabetic ketoacidotic rat

The American Journal of Physiology
J T BrosnanM E Brosnan

Abstract

Amino acid concentrations in whole blood, liver, kidney, skeletal muscle, and brain were measured and arteriovenous differences calculated for head, hindlimb, kidney, gut, and liver in control and streptozotocin-diabetic rats. In the control rats, glutamine was released by muscle and utilized by intestine, intestine released citrulline and alanine, liver removed alanine, and the kidneys removed glycine and produced serine. In diabetic rats, the major changes from the pattern of fluxes seen in the normal rat were the release of many amino acids from muscle, with glutamine and alanine predominating, and the uptake of these amino acids by the liver. Glutamine removal by the intestine was suppressed in diabetes, but a large renal uptake of glutamine was evident. Branched-chain amino acids were removed by the diabetic brain, and consequently, brain levels of a number of large neutral amino acids were decreased in diabetes.

References

Jan 1, 1975·Annual Review of Biochemistry·P Felig
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Jun 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·P FeligL Räf
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Jul 1, 1962·The American Journal of Physiology·A ROSADOG SOBERON

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Citations

Oct 12, 2007·American Journal of Physiology. Renal Physiology·Erica E EdisonJohn T Brosnan
Dec 16, 2010·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Liangcai ZhaoDonghai Lin
Sep 25, 2004·Canadian Journal of Physiology and Pharmacology·Enoka P WijekoonJohn T Brosnan
Jun 13, 2012·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Ming CaoDonghai Lin
Oct 17, 2020·Oxidative Medicine and Cellular Longevity·Antonio FranciosoMario Fontana

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