Interpenetrating polymer network scaffold of sodium hyaluronate and sodium alginate combined with berberine for osteochondral defect regeneration

Materials Science & Engineering. C, Materials for Biological Applications
Pengfei ChenShunwu Fan

Abstract

Degradation of the articular cartilage and structural remodeling of the subchondral bone are regarded as the two major pathological characteristics of osteoarthritis. This study aimed to investigate the effect of an interpenetrating polymer network (IPN) of a sodium hyaluronate and sodium alginate (HA/SA) scaffold combined with berberine (BER) on osteochondral repair. We first developed an IPN scaffold of HA/SA and evaluated its characteristics. Then, we analyzed the effect of the HA/SA scaffold combined with BER on the healing of osteochondral defects in vivo. Finally, we explored the mechanism of this system in osteochondral repair. The results showed that the system could simultaneously regenerate not only the cartilage but also the subchondral bone. Our results also revealed that the subchondral bone was partially repaired by activating the Wnt signaling pathway and the cartilage was protected from degeneration by the upregulation of autophagy. This study demonstrated that the combination of the IPN scaffold of HA/SA and BER is a promising strategy for the osteochondral defect regeneration.

Citations

Aug 15, 2020·Biochemical Society Transactions·Mark LemoineFergal J O'Brien
Jun 15, 2019·Regenerative Biomaterials·Jiawei LiZhen Gu
Apr 24, 2021·International Journal of Biological Macromolecules·Xiumei ZhangDi Huang
Jun 1, 2021·Journal of Ethnopharmacology·Yuhan ZhangWeifen Zhang
Aug 28, 2020·ACS Applied Materials & Interfaces·Zhao-Xi ZhouYing Xu

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