Interpersonal early-life trauma alters amygdala connectivity and sustained attention performance.

Brain and Behavior
Francesca C FortenbaughMichael Esterman

Abstract

Interpersonal early life trauma (I-ELT) is associated with a myriad of functional impairments in adulthood, increased risk of drug addiction, and neuropsychiatric disorders. While deficits in emotional regulation and amygdala functioning are well characterized, deficits in general cognitive functioning have also been documented. However, the neural underpinnings of cognitive dysfunction in adults with a history of I-ELT and the potential relationship between amygdala-based functional connectivity and behavioral performance are currently poorly understood. This study examined how I-ELT affects the cognitive and neural mechanisms supporting sustained attention. A total of 66 Veterans (18 with and 48 without a history of I-ELT) completed a nonemotional sustained attention task during functional MRI. The individuals with I-ELT showed significant impairments in sustained attention (i.e., higher error rates, greater response variability). This cohort exhibited increased amygdala functional connectivity with the prefrontal cortex and decreased functional connectivity with the parahippocampal gyrus when compared to those without I-ELT. These connections were significantly correlated with individual differences in sustained attention pe...Continue Reading

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Citations

Apr 14, 2019·Human Brain Mapping·Alex MitkoMichael Esterman
May 25, 2018·Journal of Child Sexual Abuse·Rebecca Shoaf KozakTamara J Cadet
Apr 22, 2021·Psychological Medicine·Audreyana Jagger-RickelsMichael Esterman
Apr 22, 2021·NeuroImage·Ayumu YamashitaMichael Esterman
Jun 4, 2021·Nature and Science of Sleep·Jooyoung LeeSeog Ju Kim

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Key Resources (RRID) Mentioned

SCR_005927
SCR_001622

Software Mentioned

LOSO
3dClustSim
ELT
SPM Anatomy Toolbox
TRACTS
AFNI
Matlab
Statistics Learning
FreeSurfer and Analysis of Functional NeuroImages ( AFNI

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