PMID: 8938206Nov 4, 1996Paper

Interpersonal improvement in chronically depressed patients treated with desipramine

Journal of Affective Disorders
J C MarkowitzJames H Kocsis

Abstract

Interpersonal difficulties of dysthymic patients are little studied. We used the Inventory of Interpersonal Problems (IIP) to assess baseline status and medication response in chronic depression. 39 chronically depressed subjects answered the IIP at entry and after 10 weeks of desipramine (DMI). Seventeen DMI responders completed IIPs after a 16-week continuation phase. Mean scores improved on all six IIP subscales during acute treatment. Continuation phase IIP improved non-significantly, approaching normative scores. Baseline IIP score correlated inversely with treatment outcome. Findings replicate in greater interpersonal detail research demonstrating rapid social amelioration in chronically depressed responders to antidepressant medication. The IIP may be useful as a predictive and interpersonal sensitivity measure in treatment studies of chronic depression.

References

Sep 1, 1976·Archives of General Psychiatry·M M Weissman, S Bothwell
Nov 1, 1989·Journal of Affective Disorders·J H KocsisD Marin
Dec 1, 1988·Journal of Consulting and Clinical Psychology·L M HorowitzV S Villaseñor
Aug 1, 1988·The American Journal of Psychiatry·J H KocsisJ Sweeney
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON

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Citations

Feb 6, 2004·General Hospital Psychiatry·George I PapakostasMaurizio Fava
Jan 11, 2007·Journal of Clinical Psychology·Marna S Barrett, Jacques P Barber
Jul 5, 2005·General Hospital Psychiatry·Erik Falkum, Per Vaglum
Oct 18, 2007·Depression and Anxiety·Joshua D LipsitzAbby J Fyer
Jul 13, 2000·Molecular Psychiatry·J GriffithsH Anisman
Apr 15, 2006·The Journal of Nervous and Mental Disease·Tally MosesMichelle Abrams

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