PMID: 7539277Apr 1, 1995Paper

Interphase cytogenetics of prostatic adenocarcinoma and precursor lesions: analysis of 25 radical prostatectomies and 17 adjacent prostatic intraepithelial neoplasias

Genes, Chromosomes & Cancer
J C AlersH van Dekken

Abstract

Twenty-five radical prostatectomy specimens were screened for the presence of numerical chromosome changes within the adenocarcinoma as well as 17 adjacent prostatic intraepithelial neoplasias (PIN) by means of interphase in situ hybridization (ISH) to routinely processed tissue sections. To this end a defined alfoid repetitive DNA probe set was used, specific for the centromeres of chromosomes 1, 7, 8, 10, 15, and Y. The cytogenetic information was correlated with histopathological and clinical features as well as with DNA ploidy. Numerical aberrations of at least one chromosome were shown in 13 of 25 cases (52%). Alterations of chromosome 8 and loss of the Y chromosome were the most frequent findings (both 20%), followed by loss of chromosomes 15 (16%) and 10 (12%). Gain of chromosome 7 was seen in 8% of cases. No aberrations of chromosomes 7, 8, 10, and 15 were found in the adjacent PIN lesions, whereas loss of the Y chromosome in both PIN and tumor occurred in two cases. Also, (low level) aneuploidy was observed in 76% of these PIN lesions. Ploidy of the carcinomas as assessed by ISH correlated well with ploidy measured by DNA flow cytometry (FCM; P < 0.02). Due to the more specific correspondence between ISH and tumor path...Continue Reading

References

Jul 1, 1977·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·I T Young
Mar 1, 1992·Human Pathology·M K Brawer
Jan 1, 1992·Genes, Chromosomes & Cancer·R LundgrenF Mitelman
Mar 1, 1992·Human Pathology·D F Gleason
Apr 1, 1992·Human Pathology·A D Deitch, R W deVere White
Apr 1, 1992·Human Pathology·A A Sandberg
Jan 1, 1992·The Prostate. Supplement·F H SchröderM Pavone-Macaluso
Jul 15, 1992·Cancer Genetics and Cytogenetics·M A MicaleS R Wolman
Nov 1, 1991·Genomics·K KunimiV P Collins
Jan 1, 1990·The Prostate·H B Carter, D S Coffey
May 1, 1991·Genes, Chromosomes & Cancer·U S BergerheimP Ekman
Aug 1, 1991·Cancer Genetics and Cytogenetics·A R BrothmanP F Schellhammer
Nov 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·B S CarterW B Isaacs
Apr 15, 1986·Cancer Genetics and Cytogenetics·N B Atkin
Nov 1, 1983·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·D W HedleyE A Musgrove
Oct 1, 1993·Genes, Chromosomes & Cancer·J A MacoskaS R Wolman
Jan 1, 1994·Genes, Chromosomes & Cancer·M G BandykJ C Liang
Apr 1, 1993·Cancer Genetics and Cytogenetics·H Van Dekken, J Alers
Apr 1, 1993·Cancer Genetics and Cytogenetics·S ArpsH Kastendieck

❮ Previous
Next ❯

Citations

Aug 1, 1996·The Prostate·D G BostwickA Lopez-Beltran
Feb 11, 1999·The Prostate·A ErbersdoblerR P Henke
Feb 18, 1998·International Journal of Cancer. Journal International Du Cancer·J B PrinsM A Versnel
Jun 1, 1996·Genes, Chromosomes & Cancer·J HerbergsA H Hopman
Mar 21, 2001·The Journal of Urology·V K DasariR Dahiya
Feb 15, 2001·Cancer Genetics and Cytogenetics·J J JordanJ V Tricoli
May 1, 1997·Cancer Genetics and Cytogenetics·A R Brothman
Mar 12, 1998·Cancer Genetics and Cytogenetics·J J KönigA Hagemeijer
Mar 4, 2000·Cancer Genetics and Cytogenetics·H M KhaledI T Magrath
Jun 29, 2002·Cancer Detection and Prevention·Marijana LijovicAlbert G Frauman
Sep 1, 1995·International Journal of Urology : Official Journal of the Japanese Urological Association·S TakahashiM M Lieber
Oct 21, 2000·Journal of Clinical Pathology·R MontironiA Lopez-Beltran
Aug 30, 2007·Journal of Zhejiang University. Science. B·V BalachandarS Mohana Devi
Aug 6, 1999·Cancer Investigation·R S VermaC J Godec
Jan 1, 1996·Progress in Histochemistry and Cytochemistry·J C Alers, H van Dekken
Mar 29, 2000·The Journal of Urology·G PerincheryR Dahiya
Apr 6, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·David I QuinnRobert L Sutherland
Apr 1, 1997·The Journal of Pathology·K Q Wolfe, C S Herrington
Jan 24, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·David G Bostwick, Junqi Qian
Jul 4, 2002·Annals of the New York Academy of Sciences·Rodolfo MontironiMarina Scarpelli
Mar 13, 1999·The Prostate·A R BrothmanX L Zhu

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