Interplay between activator-inhibitor coupling and cell-matrix adhesion in a cellular automaton model for chondrogenic patterning

Developmental Biology
Maria A KiskowskiStuart A Newman

Abstract

We present a stochastic cellular automaton model for the behavior of limb bud precartilage mesenchymal cells undergoing chondrogenic patterning. This "agent-oriented" model represents cells by points on a lattice that obey rules motivated by experimental findings. The "cells" follow these rules as autonomous agents, interacting with other cells and with the microenvironments cell activities produce. The rules include random cell motion, production and lateral deposition of a substrate adhesion molecule (SAM, corresponding to fibronectin), production and release of a diffusible growth factor ("activator," corresponding to TGF-beta) that stimulates production of the SAM, and another diffusible factor ("inhibitor") that suppresses the activity of the activator. We implemented the cellular automaton on a two-dimensional (2D) square lattice to emulate the quasi-2D micromass culture extensively used to study patterning in avian limb bud precartilage cells. We identified parameters that produce nodular patterns that resemble, in size and distribution, cell condensations in leg-cell cultures, thus establishing a correspondence between in vitro and in silico results. We then studied the in vitro and in silico micromass cultures experime...Continue Reading

References

Aug 17, 1979·Science·S A Newman, H L Frisch
Dec 1, 1990·Differentiation; Research in Biological Diversity·L Edelstein-Keshet, G B Ermentrout
Jan 1, 1990·Journal of Mathematical Biology·L Edelstein-Keshet, G B Ermentrout
Dec 1, 1988·Trends in Genetics : TIG·S A Newman
Feb 1, 1988·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·D F Paulsen, M Solursh
Jun 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·B P TooleJ Gross
Jan 1, 1984·Journal of Mathematical Biology·J D Murray, G F Oster
Jan 1, 1995·Journal of Mathematical Biology·G A Ngwa, P K Maini
Jan 7, 1993·Journal of Theoretical Biology·G B Ermentrout, L Edelstein-Keshet
Mar 1, 1993·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·J A Glazier, F Graner
Feb 2, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·B K Hall, T Miyake
Mar 31, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·T Miura, K Shiota
Aug 5, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·H Meinhardt, A Gierer
Dec 5, 2000·Journal of Mathematical Biology·K J PainterH G Othmer
Mar 29, 2001·Proceedings of the National Academy of Sciences of the United States of America·A F Marée, P Hogeweg
Jan 1, 1988·Mathematical Biosciences·D T KaplanR J Cohen
Nov 9, 2001·Microbiology·J U KreftM C van Loosdrecht
Apr 18, 2002·Proceedings. Biological Sciences·Richard O Prum, Scott Williamson
Sep 21, 2002·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Anthony M Delise, Rocky S Tuan
Apr 2, 2003·Development·Isaac Salazar-CiudadStuart A Newman
Apr 12, 2003·Developmental Cell·C Tickle
Aug 22, 2003·Proceedings of the National Academy of Sciences of the United States of America·Robert DillonHans G Othmer
Feb 1, 1964·Developmental Biology·E ZWILLING
Feb 7, 2004·Bioinformatics·J A IzaguirreJ A Glazier
Aug 13, 2004·Proceedings. Biological Sciences·H G E HentschelStuart A Newman
Aug 1, 1985·The American Journal of Anatomy·B BrandH J Jacob
Jan 1, 1951·Journal of Morphology·V HAMBURGER, H L HAMILTON

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Citations

Aug 13, 2004·Proceedings. Biological Sciences·H G E HentschelStuart A Newman
Jul 20, 2006·Journal of the Royal Society, Interface·R ChaturvediM S Alber
May 1, 2007·PLoS Computational Biology·Scott ChristleyStuart A Newman
Nov 30, 2011·TheScientificWorldJournal·Diego GuidolinGiovanna Albertin
Dec 12, 2012·Mathematical Biosciences·Yong-Tao ZhangStuart A Newman
Mar 28, 2009·Journal of Theoretical Biology·Tsuyoshi HirashimaYoshihiro Morishita
Jun 14, 2012·Birth Defects Research. Part C, Embryo Today : Reviews·T GlimmM A Kiskowski
Oct 19, 2006·IEEE/ACM Transactions on Computational Biology and Bioinformatics·Trevor M CickovskiJesús A Izaguirre
Dec 21, 2013·Journal of Theoretical Biology·T GlimmS A Newman
Dec 6, 2005·Developmental Biology·Roeland M H MerksJames A Glazier
Jan 30, 2008·Birth Defects Research. Part C, Embryo Today : Reviews·Stuart A Newman, Ramray Bhat
Sep 15, 2005·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Stuart A Newman, Gerd B Müller
Mar 27, 2020·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Tilmann GlimmStuart A Newman
Jun 29, 2006·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Mark AlberPavel M Lushnikov
Aug 9, 2021·Bio Systems·Stuart A NewmanTilmann Glimm

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