Interplay between acute phase response and coagulation/fibrinolysis in chronic spontaneous urticaria

Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology
R GrzankaA Kasperska-Zajac

Abstract

Chronic spontaneous urticaria (CSU) is associated with activation of systemic inflammatory response and coagulation/fibrinolysis. To study whether there is a relationship between the acute phase response and coagulation/fibrinolysis in chronic spontaneous urticaria (CSU) patients. Serum concentrations of C-reactive protein (CRP) and interleukin 6 (IL-6), key markers of acute phase response and of D-dimer, a marker of fibrin turnover were investigated in 58 CSU patients assessed with the urticaria activity score (UAS) and the controls. Serum concentrations of IL-6, CRP, and D-dimer were significantly higher in CSU patients as compared with the controls. We found statistically significant correlations between D-dimers concentrations and the inflammatory markers: CRP and IL-6 as well as UAS. Markers of inflammation (IL-6 and CRP) and of fibrinolysis (D-dimer) are related to each other in CSU, suggesting a possible cross-talk between inflammation and coagulation/fibrinolysis. It might be implicated in pathogenesis of the disease and may be associated with higher risks of cardiovascular diseases in CSU patients.

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Jan 18, 2018·Allergy·T ZuberbierUNKNOWN Endorsed by the following societies: AAAAI, AAD, AAIITO, ACAAI, AEDV, APAAACI, ASBAI, ASCIA, BAD, BSACI, CDA, CMICA, CSACI,

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Citations

Sep 30, 2020·Expert Opinion on Pharmacotherapy·Kam Lun HonVivian W Y Lee
May 16, 2020·Archives of Dermatological Research·Vanessa Lucilia Silveira de Medeiros, Lucas Fagundes Teixeira Silva
Mar 27, 2019·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·R GrzankaA Kasperska-Zajac
Jul 10, 2019·Frontiers in Immunology·Massimo CugnoAngelo Valerio Marzano
May 16, 2020·Archives of Dermatological Research·Vanessa Lucilia Silveira de Medeiros, Lucas Fagundes Teixeira Silva
Apr 7, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Ana M Giménez-ArnauAllen P Kaplan

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Methods Mentioned

BETA
ESR
electrophoresis
enzyme-linked immunosorbent assay

Software Mentioned

FricTest
STATISTICA

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