Interplay between adenylate metabolizing enzymes and AMP-activated protein kinase

The FEBS Journal
Marcella CamiciMaria Grazia Tozzi

Abstract

Purine nucleotides are involved in a variety of cellular functions, such as energy storage and transfer, and signalling, in addition to being the precursors of nucleic acids and cofactors of many biochemical reactions. They can be generated through two separate pathways, the de novo biosynthesis pathway and the salvage pathway. De novo purine biosynthesis leads to the formation of IMP, from which the adenylate and guanylate pools are generated by two additional steps. The salvage pathways utilize hypoxanthine, guanine and adenine to generate the corresponding mononucleotides. Despite several decades of research on the subject, new and surprising findings on purine metabolism are constantly being reported, and some aspects still need to be elucidated. Recently, purine biosynthesis has been linked to the metabolic pathways regulated by AMP-activated protein kinase (AMPK). AMPK is the master regulator of cellular energy homeostasis, and its activity depends on the AMP : ATP ratio. The cellular energy status and AMPK activation are connected by AMP, an allosteric activator of AMPK. Hence, an indirect strategy to affect AMPK activity would be to target the pathways that generate AMP in the cell. Herein, we report an up-to-date revie...Continue Reading

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Citations

Mar 11, 2020·Microbial Biotechnology·Antoine DanchinConghui You
Jun 17, 2020·Neuroscience Bulletin·Bruno G Frenguelli, Nicholas Dale
Aug 9, 2020·OncoTargets and Therapy·Wei HanWei Guan
Aug 16, 2019·Bioscience Reports·Jia LiuJiyan Leng
Nov 18, 2018·International Journal of Molecular Sciences·Mercedes Garcia-GilMaria Grazia Tozzi
Jan 8, 2021·Frontiers in Pharmacology·Marcella CamiciMaria Grazia Tozzi
Jan 19, 2021·American Journal of Physiology. Renal Physiology·Edgar A JaimesLeopoldo Raij
Apr 20, 2021·Frontiers in Cell and Developmental Biology·Xiaoting ChenHaibing Chen
Jun 1, 2021·Frontiers in Pharmacology·Mercedes Garcia-GilMaria Grazia Tozzi

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