PMID: 19923894Nov 20, 2009Paper

Interplay between BMP4 and IL-7 in human intrathymic precursor cells

Cell Cycle
Alberto VarasAngeles Vicente

Abstract

Bone morphogenetic proteins (BMPs) play a pivotal role during vertebrate embryogenesis and organogenesis, and have also been described to function in regulating cell fate and determination in self-renewing tissues in adults. Recent results have demonstrated that the different components of the BMP2/4 signaling pathway are expressed in the human thymus. In this study, we provide evidence that BMP4 and IL-7 interplay is important in the maintenance of the human thymic progenitor population. Intrathymic CD34(+) cells express BMP receptors (BMPRIA, BMPRIB, ActRIA, BMPRII), signal transduction molecules (Smad1, 5, 8 and 4), and produce BMP4. Neutralization of endogenous BMP4 by treatment with the antagonist Noggin reduces thymic precursor cell survival, and the addition of exogenous BMP4 decreases their proliferation. The treatment of chimeric human-mouse fetal thymus organ cultures with BMP4 inhibits cell expansion, arrests thymocyte differentiation, and leads to the accumulation of human CD34(+) precursor cells. This effect is mainly attributed to the ability of BMP4 to counteract the IL-7-induced proliferation and differentiation of CD34(+) cells. BMP4 downregulates in the precursor cell population the expression of CD127 and inh...Continue Reading

Citations

Nov 26, 2010·Immunology and Cell Biology·Víctor G MartínezAlberto Varas
Jan 10, 2012·Developmental and Comparative Immunology·Dongyuan MaFeng Liu
Feb 18, 2014·European Journal of Immunology·Víctor G MartínezAlberto Varas
Dec 8, 2010·Cell Cycle·Rebeca A Frum, Yanping Zhang
Feb 6, 2014·Cell Cycle·Susan V OutramCynthia Umukoro
Nov 8, 2011·The American Journal of Pathology·Chi Young OkFrancisco Vega
Jun 26, 2015·PloS One·Víctor G MartínezAlberto Varas
Jan 14, 2018·Science Immunology·Tobias WertheimerMarcel R M van den Brink
Nov 26, 2016·Nature Reviews. Immunology·WanJun Chen, Peter Ten Dijke
Mar 23, 2021·Communications Biology·Shenjie ZhongZhenhui Liu

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