Interplay between carbohydrate and lipid in recognition of glycolipid antigens by natural killer T cells.

Annals of the New York Academy of Sciences
Bo PeiMitchell Kronenberg

Abstract

Natural killer T (NKT) cells are a T cell subpopulation that were named originally based on coexpression of receptors found on natural killer (NK) cells, cells of the innate immune system, and by T lymphocytes. The maturation and activation of NKT cells requires presentation of glycolipid antigens by CD1d, a cell surface protein distantly related to the major histocompatibility complex (MHC)-encoded antigen presenting molecules. This specificity distinguishes NKT cells from most CD4(+) and CD8(+) T cells that recognize peptides presented by MHC class I and class II molecules. The rapid secretion of a large amount of both Th1 and Th2 cytokines by activated NKT cells endows them with the ability to play a vital role in the host immune defense against various microbial infections. In this review, we summarize progress on identifying the sources of microbe-derived glycolipid antigens recognized by NKT cells and the biochemical basis for their recognition.

References

Mar 1, 1979·European Journal of Immunology·A J McMichaelC Milstein
Sep 1, 1979·Journal of Clinical Pathology·V HajiroussouC A Pinning
Jan 1, 1991·European Journal of Immunology·C A Bilsland, C Milstein
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·L H MartinC Milstein
Apr 1, 1989·The Journal of Investigative Dermatology·J LongleyR Edelson
Oct 1, 1988·The Journal of Pathology·M E SmithW F Bodmer
Dec 1, 1984·Journal of Clinical Microbiology·Y GlupczynskiE Yourassowsky
Jun 1, 1981·Journal of Clinical Microbiology·P M Southern, A E Kutscher
Jan 1, 1995·Annual Review of Biochemistry·M T Heemels, H Ploegh
Jun 9, 1995·Journal of Medicinal Chemistry·M MoritaH Fukushima
Jan 1, 1994·Annual Review of Immunology·P Cresswell
Jan 1, 1993·Annual Review of Immunology·R N Germain, D H Margulies
Nov 18, 1997·Cell·R Medzhitov, C A Janeway
Mar 23, 2000·The Journal of Experimental Medicine·F M SpadaM B Brenner
Jun 6, 2000·The Journal of Experimental Medicine·K BenlaghaA Bendelac
Sep 7, 2000·The Journal of Experimental Medicine·J L MatsudaM Kronenberg
Oct 25, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·H KumarL K Bockenstedt
Jan 9, 2001·Seminars in Immunology·F Calabi, C Milstein
Feb 7, 2001·Science·T I PrigozyM Kronenberg
Jul 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stéphane SidobreMitchell Kronenberg
Sep 28, 2002·FEMS Microbiology Letters·Kazuyoshi KawaharaYasuo Seto
Nov 5, 2002·Nature Immunology·Michael S VincentMichael B Brenner
Apr 16, 2003·The Journal of Experimental Medicine·Grazia GalliSergio Abrignani
Apr 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Carlos CantuLuc Teyton
Jun 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Gil Ben-MenachemRachel Schneerson
Aug 7, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tony KennaLucy Golden Mason
Aug 20, 2003·The Journal of Investigative Dermatology·Victor Peña-CruzMasahiko Sugita
Oct 28, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Carlo SelmiM Eric Gershwin
Oct 28, 2003·Nature Immunology·Manfred BriglMichael B Brenner
Jan 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·John R OrtaldoRobert H Wiltrout
Jan 13, 2004·Nature Immunology·Suk-Jo Kang, Peter Cresswell
Jan 13, 2004·Nature Immunology·Florian WinauUlrich E Schaible

❮ Previous
Next ❯

Citations

Mar 15, 2013·Trends in Immunology·Jenny L JohnsonBrian A Cobb
Aug 24, 2012·PLoS Pathogens·Jennifer A JunoKeith R Fowke
Jul 31, 2013·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Yolanda D MahnkeMario Roederer
Jun 26, 2014·The FEBS Journal·Changrong GeMartin Lindén
Mar 26, 2015·Current Opinion in Immunology·Rosanna M McEwen-SmithVincenzo Cerundolo
Jul 13, 2013·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Yuki KinjoMitchell Kronenberg
Feb 14, 2016·European Journal of Immunology·John-Paul JukesVincenzo Cerundolo
Aug 26, 2016·Organic Letters·Ahmad S AltitiDavid R Mootoo
Apr 8, 2017·Archivum Immunologiae Et Therapiae Experimentalis·Radoslaw KaczmarekMarcin Czerwinski
Oct 21, 2015·Nature Immunology·Dale I GodfreyD Branch Moody
Jul 10, 2013·Cellular and Molecular Life Sciences : CMLS·M RakhshandehrooM Boes
Dec 10, 2016·Frontiers in Immunology·Joshua J MichelAbbe N Vallejo
Aug 26, 2016·Glycobiology·Ajit Varki
Dec 20, 2020·Molecular Immunology·Gavin F PainterIan F Hermans
Jan 9, 2021·Biomarker Research·Qi WuShengrong Sun

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.