Interplay between cardiac transcription factors and non-coding RNAs in predisposing to atrial fibrillation

Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte
Alexander T Mikhailov, Mario Torrado

Abstract

There is growing evidence that putative gene regulatory networks including cardio-enriched transcription factors, such as PITX2, TBX5, ZFHX3, and SHOX2, and their effector/target genes along with downstream non-coding RNAs can play a potentially important role in the process of adaptive and maladaptive atrial rhythm remodeling. In turn, expression of atrial fibrillation-associated transcription factors is under the control of upstream regulatory non-coding RNAs. This review broadly explores gene regulatory mechanisms associated with susceptibility to atrial fibrillation-with key examples from both animal models and patients-within the context of both cardiac transcription factors and non-coding RNAs. These two systems appear to have multiple levels of cross-regulation and act coordinately to achieve effective control of atrial rhythm effector gene expression. Perturbations of a dynamic expression balance between transcription factors and corresponding non-coding RNAs can provoke the development or promote the progression of atrial fibrillation. We also outline deficiencies in current models and discuss ongoing studies to clarify remaining mechanistic questions. An understanding of the function of transcription factors and non-c...Continue Reading

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Citations

Sep 26, 2019·Frontiers in Cardiovascular Medicine·Silje Madeleine KalstøIngrid E Christophersen
Jul 1, 2020·Open Biology·Diego VillarAndrew Tinker
Jan 14, 2021·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Rosa Doñate PuertasPhilippe Chevalier

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Methods Mentioned

BETA
biopsy
transfection
biopsies
transfections

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