Interplay between cellular redox oscillations and circadian clocks

Diabetes, Obesity & Metabolism
Guillaume Rey, Akhilesh B Reddy

Abstract

The circadian clock is a cellular timekeeping mechanism that helps organisms from bacteria to humans to organize their behaviour and physiology around the solar cycle. Current models for circadian timekeeping incorporate transcriptional/translational feedback loop mechanisms in the predominant model systems. However, recent evidence suggests that non-transcriptional oscillations such as metabolic and redox cycles may play a fundamental role in circadian timekeeping. Peroxiredoxins, an antioxidant protein family, undergo rhythmic oxidation on the circadian time scale in a variety of species, including bacteria, insects and mammals, but also in red blood cells, a naturally occurring, non-transcriptional system. The profound interconnectivity between circadian and redox pathways strongly suggests that a conserved timekeeping mechanism based on redox cycles could be integral to generating circadian rhythms.

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Citations

May 17, 2017·Antioxidants & Redox Signaling·Marrit PutkerJohn S O'Neill
Aug 6, 2017·Cold Spring Harbor Perspectives in Biology·Nikolay B MilevAkhilesh B Reddy
Sep 20, 2018·Diabetes, Obesity & Metabolism·Volodymyr PetrenkoCharna Dibner
Feb 6, 2020·The European Journal of Neuroscience·Nicolas C Nicolaides, George P Chrousos
Apr 5, 2020·Antioxidants & Redox Signaling·Thomas MünzelAndreas Daiber
May 4, 2017·American Journal of Physiology. Endocrinology and Metabolism·Jingyi QianAleksey V Matveyenko
Oct 13, 2020·Frontiers in Endocrinology·María García-CostelaJosefa León

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