Interplay between Clonal Hematopoiesis of Indeterminate Potential and Metabolism.

Trends in Endocrinology and Metabolism : TEM
Man K S LeeAndrew J Murphy

Abstract

Clonal hematopoiesis of indeterminate potential (CHIP), defined as a clone of hematopoietic cells consisting of a single acquired mutation during a lifetime, has recently been discovered to be a major risk factor for atherosclerotic cardiovascular disease (CVD). As such, this phenomenon has sparked interest into the role that these single mutations may play in CVD. Atherosclerotic CVD is a complex disease and we have previously shown that atherosclerosis can be accelerated by metabolic- or autoimmune-related risk factors such as diabetes, obesity, and rheumatoid arthritis. In this review, we discuss the role of CHIP, the interplay between CHIP and metabolic diseases, as well as how metabolism of hematopoietic stem cells (HSCs) could regulate CHIP-related HSC fate.

Citations

Jan 15, 2021·Arteriosclerosis, Thrombosis, and Vascular Biology·Man K S LeeAndrew J Murphy
Nov 9, 2020·Molecular Aspects of Medicine·George HajishengallisTriantafyllos Chavakis
Nov 10, 2020·Molecular Aspects of Medicine·Adélie DumontLaurent Yvan-Charvet
Feb 24, 2021·Journal of the American Heart Association·Bernhard HaringJoAnn E Manson
Aug 27, 2021·Circulation Journal : Official Journal of the Japanese Circulation Society·María A Zuriaga, José J Fuster
Jan 6, 2022·Science Translational Medicine·Wandi ZhuCalum A MacRae

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