Interplay between miRNAs and host genes and their role in cancer

Briefings in Functional Genomics
Baohong LiuQi Liu

Abstract

MicroRNAs (miRNAs) are small endogenous non-coding functional RNAs that post-transcriptionally regulate gene expression. They play essential roles in nearly all biological processes including cell development and differentiation, DNA damage repair, cell death as well as intercellular communication. They are highly involved in cancer, acting as tumor suppressors and/or promoters to modulate cell proliferation, epithelial-mesenchymal transition and tumor invasion and metastasis. Recent studies have shown that more than half of miRNAs are located within protein-coding or non-coding genes. Intragenic miRNAs and their host genes either share the promoter or have independent transcription. Meanwhile, miRNAs work as partners or antagonists of their host genes by fine-tuning their target genes functionally associated with host genes. This review outlined the complicated relationship between intragenic miRNAs and host genes. Focusing on miRNAs known as oncogenes or tumor suppressors in specific cancer types, it studied co-expression relationships between these miRNAs and host genes in the cancer types using TCGA data sets, which validated previous findings and revealed common, tumor-specific and even subtype-specific patterns. These obs...Continue Reading

References

Nov 16, 2002·Proceedings of the National Academy of Sciences of the United States of America·George Adrian CalinCarlo M Croce
Jun 27, 2006·Computational Biology and Chemistry·J GorodkinM Fredholm
Sep 23, 2006·Developmental Biology·Baohong ZhangTodd A Anderson
Jan 27, 2007·The EMBO Journal·Young-Kook Kim, V Narry Kim
Mar 17, 2007·The Journal of Biological Chemistry·Shuomin ZhuYin-Yuan Mo
May 1, 2007·DNA and Cell Biology·Sung-Chou LiWen-Chang Lin
Oct 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Esmerina TiliCarlo Maria Croce
Nov 6, 2007·Frontiers in Bioscience : a Journal and Virtual Library·Marjorie P Perron, Patrick Provost
Oct 15, 2008·Proceedings of the National Academy of Sciences of the United States of America·Daniel H KimJohn J Rossi
Dec 6, 2008·Genes & Development·Fatih OzsolakDavid E Fisher
Dec 6, 2008·Science·Amy C SeilaPhillip A Sharp
Jan 1, 2009·Biochemical and Biophysical Research Communications·Yoshimasa SaitoGangning Liang
Apr 11, 2009·Proceedings of the National Academy of Sciences of the United States of America·Ryan M O'ConnellDavid Baltimore
Jul 15, 2009·Cell Cycle·Amy C SeilaPhillip A Sharp
Dec 22, 2009·The Journal of Urology·Tsz-Fung F ChowGeorge M Yousef
Dec 30, 2009·International Journal of Cancer. Journal International Du Cancer·Haruo NakanoTetsuo Yoshida
Feb 23, 2010·Nature Cell Biology·Li MaRobert A Weinberg
Jun 15, 2010·Molecular Cell·Wenwei HuZhaohui Feng
Sep 28, 2010·Biotechnology Letters·Niall BarronMartin Clynes
Oct 5, 2010·Nature Reviews. Drug Discovery·Ramiro GarzonCarlo M Croce
Oct 6, 2010·BMC Genomics·Ludwig Christian G HinskeLucila Ohno-Machado
Oct 28, 2010·Genomics·Brian C Schanen, Xiaoman Li
Nov 3, 2010·Nucleic Acids Research·Ana Kozomara, Sam Griffiths-Jones
Dec 9, 2010·Cancer Biology & Therapy·Xuan PanRui Wang
May 3, 2011·Current Genomics·Leigh-Ann Macfarlane, Paul R Murphy
Jul 15, 2011·The Journal of Clinical Endocrinology and Metabolism·Vincenza LeoneAlfredo Fusco
Aug 30, 2011·Oncogene·T PapagiannakopoulosK S Kosik
Nov 9, 2011·Molecular Cancer Research : MCR·Shin HamadaTooru Shimosegawa
Jan 10, 2012·Genome Biology and Evolution·Masafumi NozawaMasatoshi Nei

❮ Previous
Next ❯

Citations

Jun 5, 2020·Artificial Cells, Nanomedicine, and Biotechnology·Dan JiQiong Fang
Mar 17, 2020·Frontiers in Genetics·Michelle M J MensMohsen Ghanbari
Aug 1, 2020·International Journal of Molecular Sciences·Hsiuying Wang
Oct 9, 2019·International Journal of Molecular Sciences·Hui-Yi LohMohd Azuraidi Osman
Sep 19, 2020·Wiley Interdisciplinary Reviews. RNA·Qinyu SunKannanganattu V Prasanth
Sep 17, 2020·International Journal of Molecular Sciences·Athina A KyriaziStavroula Baritaki
Nov 20, 2020·The Journal of Obstetrics and Gynaecology Research·Lily CaiYu Chen
Jan 12, 2020·Cytokine & Growth Factor Reviews·Giada PontecorviGianfranco Mattia
Dec 3, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Xu Cao, Qiu-Ling Fan
Feb 13, 2021·Molecular Human Reproduction·Sarah J Holdsworth-CarsonPeter A W Rogers
Jul 13, 2020·Current Cancer Drug Targets·Ravishkumar L AkshayaNagarajan Selvamurugan
May 2, 2021·Cell Death & Disease·Chencheng HanRong Yin
May 29, 2021·Environmental Science and Pollution Research International·Marwa M MahmoudNadia M Hamdy
Apr 20, 2021·Molecular Biology and Evolution·Thomas DesvignesJohn H Postlethwait
Jun 5, 2021·Frontiers in Immunology·Yingying XingLufeng Zheng
Jul 3, 2021·Cancers·Paulína Pidíková, Iveta Herichová
Sep 16, 2021·Genes & Genomics·Ying WangZhipeng Li
Dec 22, 2021·Phytotherapy Research : PTR·Luis M Ruiz-ManriquezSujay Paul

❮ Previous
Next ❯

Methods Mentioned

BETA
histone acetylation

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.