PMID: 26350341Sep 10, 2015Paper

Interplay Between Nitric Oxide and Brain-Derived Neurotrophic Factor in Neuronal Plasticity

CNS & Neurological Disorders Drug Targets
Caroline BiojoneEero Castren

Abstract

Nitric oxide is a gaseous neuromodulator that displays a core role in several neuronal processes. Beyond regulating the release of neurotransmitters, nitric oxide also plays a role in cell differentiation and maturation in the central nervous system. Although the mode of action of nitric oxide is not fully understood, it involves the activation of soluble guanylate cyclase as well as the nitration and S-nitrosylation of specific amino acid residues in other proteins. Brain-derived neurotrophic factor is a member of neurotrophic factor family and, acting through its receptor tropomyosinrelated kinase B, increases the production of nitric oxide, modulates neuronal differentiation and survival, and plays a crucial role in synaptic plasticity, such as long-term potentiation. Furthermore, nitric oxide is an important regulator of the production of these factors. The aim of the present review is to present a condensed view of the evidence related to the interaction between nitric oxide and brain-derived neurotrophic factor. Additionally, we conducted bioinformatics analysis based on the amino acid sequences of brain-derived neurotrophic factor and tropomyosin-related kinase receptors, and proposed that nitric oxide might nitrate/S-ni...Continue Reading

Citations

Apr 19, 2016·Expert Review of Neurotherapeutics·Carlos CamposSérgio Machado
Apr 12, 2017·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Wen-Guang XiaJuan Wang
Jun 18, 2017·Cellular and Molecular Neurobiology·Przemysław KowiańskiJanusz Moryś
Jun 17, 2016·The European Journal of Neuroscience·Hayat BanoujaafarChristine Marie
Nov 22, 2017·Proceedings of the National Academy of Sciences of the United States of America·Jessica L AblesInes Ibañez-Tallon
Jan 17, 2019·Cell and Tissue Research·Samia R L JocaGregers Wegener
Apr 11, 2019·Clinical Medicine Insights. Cardiology·Maria Lm RêgoEduardo B Fontes
Dec 27, 2018·International Journal of Molecular Sciences·Huiju Lee, Yoon Kyung Choi
Feb 20, 2018·Translational Neurodegeneration·Sandesh PanthiKripa Gautam
May 14, 2020·Journal of the Science of Food and Agriculture·Oluwafemi Adeleke OjoAmos Sunday Onikanni
Jun 10, 2020·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Graziele Freitas de BemAngela Castro Resende
Nov 11, 2020·The European Journal of Neuroscience·Izaque de Sousa MacielSâmia R L Joca
Nov 17, 2020·Frontiers in Aging Neuroscience·Lin ChenYong Tang
Nov 16, 2021·Frontiers in Cellular Neuroscience·Adonis SferaZisis Kozlakidis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.