Interplay between Nox2 Activity and Platelet Activation in Patients with Sepsis and Septic Shock: A Prospective Study.

Oxidative Medicine and Cellular Longevity
Giusy TiseoFalcone Marco

Abstract

Although preclinical studies highlighted the potential role of NADPH oxidase (NOX) in sepsis, only few studies evaluated the oxidative stress in patients with sepsis and septic shock. The objective of the study is to appraise the oxidative stress status and platelet function in patients with sepsis and septic shock compared to healthy controls. Patients with sepsis or septic shock admitted to the hospital Policlinico Umberto I (Sapienza University, Rome) underwent a blood sample collection within 1 hour from admission. Platelet aggregation, serum thromboxane B2 (TxB2), soluble NOX2-derived peptides (sNox2-dp), and hydrogen peroxide breakdown activity (HBA) were measured and compared to those of healthy volunteers. Overall, 33 patients were enrolled; of these, 20 (60.6%) had sepsis and 13 (39.4%) septic shock. Compared to healthy controls (n = 10, age 67.8 ± 3.2, male 50%), patients with sepsis and septic shock had higher platelet aggregation (49% (IQR 45-55), 60% (55.75-67.25), and 73% (IQR 69-80), respectively, p < 0.001), higher serum TxB2 (77.5 (56.5-86.25), 122.5 (114-131.5), and 210 (195-230) pmol/L, respectively, p < 0.001), higher sNox2-dp (10 (7.75-12), 19.5 (17.25-21), and 33 (29.5-39) pg/mL, respectively, p < 0.001), ...Continue Reading

References

Nov 19, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Stefania BasiliUNKNOWN CALC Group
Jan 3, 2012·Thrombosis Research·Francesco Violi, Pasquale Pignatelli
Mar 20, 2012·Diabetes·Roberto CangemiFrancesco Violi
Dec 18, 2013·Antioxidants & Redox Signaling·Roberto CangemiUNKNOWN SIXTUS study group
Apr 8, 2015·Prostaglandins & Other Lipid Mediators·Daniele PastoriFrancesco Violi
Feb 24, 2016·JAMA : the Journal of the American Medical Association·Mervyn SingerDerek C Angus
Feb 11, 2018·European Journal of Internal Medicine·Marco FalconeAntonino Mazzone
Mar 27, 2018·British Journal of Clinical Pharmacology·Roberto CarnevaleFrancesco Violi
May 26, 2018·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Xi-Ling WangYi Zhun Zu
Jun 27, 2018·Intensive Care Medicine·Karan Singh, Paul Mayo
Jul 4, 2018·International Journal of Antimicrobial Agents·A RussoUNKNOWN REIPI/ESGBIS/INCREMENT investigators
Mar 20, 2019·Intensive Care Medicine·Guillaume GeriAntoine Vieillard-Baron
Feb 1, 2020·Critical Care : the Official Journal of the Critical Care Forum·Marco FalconeFrancesco Menichetti

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Citations

Oct 1, 2021·Experimental Lung Research·Shengsong ChenQingyuan Zhan

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Methods Mentioned

BETA
ELISA

Software Mentioned

SPSS
R

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