Interplay between obesity and associated metabolic disorders: new insights into the gut microbiota

Current Opinion in Pharmacology
Patrice D Cani, Nathalie M Delzenne


Obesity and associated metabolic disorders are worldwide epidemic. The literature provides new evidence that gut microbiota dysbiosis (at the phyla, genus, or species level) affects host metabolism and energy storage. Here we discuss new findings that may explain how gut microbiota can be involved in the development or in the control of obesity and associated low-grade inflammation. New powerful molecular biology methods and the use of gnotobiotic animal allowed to analyze the molecular link between gut bacteria and the host. Moreover, even if more studies are needed to unravel how changing gut microbiota impacts on the development of obesity and related metabolic alterations, probiotic and prebiotic approach appear as potential interesting treatments to reverse host metabolic alterations linked to gut microbiota dysbiosis.

Associated Clinical Trials


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Aug 27, 2013·Antonie van Leeuwenhoek·Ozgün Candan Onarman UmuDzung B Diep
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Oct 6, 2010·The British Journal of Nutrition·Marcel RoberfroidAgnes Meheust
Jan 21, 2012·The British Journal of Nutrition·Linda V Thomas, Theo Ockhuizen
Jun 22, 2012·The British Journal of Nutrition·Ana Paula Boroni MoreiraRita de Cássia Gonçalves Alfenas
Feb 13, 2013·The British Journal of Nutrition·Nathalie M DelzennePatrice D Cani
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