Interplay between obesity and associated metabolic disorders: new insights into the gut microbiota

Current Opinion in Pharmacology
Patrice D Cani, Nathalie M Delzenne

Abstract

Obesity and associated metabolic disorders are worldwide epidemic. The literature provides new evidence that gut microbiota dysbiosis (at the phyla, genus, or species level) affects host metabolism and energy storage. Here we discuss new findings that may explain how gut microbiota can be involved in the development or in the control of obesity and associated low-grade inflammation. New powerful molecular biology methods and the use of gnotobiotic animal allowed to analyze the molecular link between gut bacteria and the host. Moreover, even if more studies are needed to unravel how changing gut microbiota impacts on the development of obesity and related metabolic alterations, probiotic and prebiotic approach appear as potential interesting treatments to reverse host metabolic alterations linked to gut microbiota dysbiosis.

Associated Clinical Trials

Citations

Sep 18, 2010·Inflammatory Bowel Diseases·Janelle C Arthur, Christian Jobin
Aug 27, 2013·Antonie van Leeuwenhoek·Ozgün Candan Onarman UmuDzung B Diep
Mar 25, 2011·Current Diabetes Reports·Nathalie M Delzenne, Patrice D Cani
Oct 6, 2010·The British Journal of Nutrition·Marcel RoberfroidAgnes Meheust
Jan 21, 2012·The British Journal of Nutrition·Linda V Thomas, Theo Ockhuizen
Jun 22, 2012·The British Journal of Nutrition·Ana Paula Boroni MoreiraRita de Cássia Gonçalves Alfenas
Feb 13, 2013·The British Journal of Nutrition·Nathalie M DelzennePatrice D Cani
Jan 11, 2013·The British Journal of Nutrition·Jorge R MujicoAscensión Marcos
Jun 15, 2010·The Proceedings of the Nutrition Society·Yolanda SanzPaola Gauffin
Oct 4, 2012·Animal : an International Journal of Animal Bioscience·S G BuzoianuP G Lawlor
Sep 23, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·K Clément
Jul 19, 2011·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·L RibonnetY Larondelle
Apr 26, 2013·Briefings in Functional Genomics·Patrice D Cani
Aug 14, 2010·Mediators of Inflammation·Rosário Monteiro, Isabel Azevedo
Oct 11, 2012·Gastroenterology Research and Practice·Usha Vyas, Natarajan Ranganathan
Jun 3, 2011·The Journal of Clinical Investigation·Herbert Tilg, Arthur Kaser
Aug 7, 2012·The Journal of Clinical Investigation·Henk S SchipperEric Kalkhoven
Feb 2, 2011·Gut Pathogens·Whitney P Bowe, Alan C Logan
May 11, 2012·PloS One·Stefan G BuzoianuPeadar G Lawlor
Mar 29, 2014·Journal of Nutrition and Metabolism·Lovisa HeymanKarin Berger
Nov 28, 2013·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Wilfried SzymczakMartin Hrabě de Angelis
Jul 21, 2011·Journal of Biomedicine & Biotechnology·Satya PrakashArielle Cantor
Jan 10, 2012·Annual Review of Food Science and Technology·Petra A M J ScholtensJan Knol
May 17, 2011·Annual Review of Nutrition·Nathalie M Delzenne, Patrice D Cani
Nov 20, 2014·BMC Gastroenterology·Stephan C BischoffJerry M Wells
Feb 13, 2013·Clinical Chemistry·Sridevi DevarajJames Versalovic
Apr 26, 2011·Digestive Diseases and Sciences·Joe Alcock
Jan 1, 2013·Bioscience of Microbiota, Food and Health·Alexander Suvorov
Feb 18, 2016·Nutrition Reviews·Marie-Edith Arnal, Jean-Paul Lallès
Dec 30, 2014·International Journal of Environmental Research and Public Health·Marina SanchezAngelo Tremblay
Nov 20, 2015·Molecular Nutrition & Food Research·Alice ChaplinAndreu Palou
Sep 18, 2013·The Journal of Nutritional Biochemistry·Frank A DucaMihai Covasa
Oct 5, 2010·Trends in Endocrinology and Metabolism : TEM·A Christine Könner, Jens C Brüning

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.