Interplay between platelets and coagulation.

Blood Reviews
Yaqiu SangDana Huskens

Abstract

Haemostasis stops bleeding at the site of vascular injury and maintains the integrity of blood vessels through clot formation. This regulated physiological process consists of complex interactions between endothelial cells, platelets, von Willebrand factor and coagulation factors. Haemostasis is initiated by a damaged vessel wall, followed with a rapid adhesion, activation and aggregation of platelets to the exposed subendothelial extracellular matrix. At the same time, coagulation factors aggregate on the procoagulant surface of activated platelets to consolidate the platelet plug by forming a mesh of cross-linked fibrin. Platelets and coagulation mutually influence each other and there are strong indications that, thanks to the interplay between platelets and coagulation, haemostasis is far more effective than the two processes separately. Clinically this is relevant because impaired interaction between platelets and coagulation may result in bleeding complications, while excessive platelet-coagulation interaction induces a high thrombotic risk. In this review, platelets, coagulation factors and the complex interaction between them will be discussed in detail.

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Citations

Aug 6, 2020·Bioengineering·Tomoyuki KawaseCarlos Fernando Mourão
Nov 4, 2020·Clinical Science·Sarah M HicksElizabeth E Gardiner
May 6, 2021·International Journal of Molecular Sciences·Olga ShevchukAlbert Sickmann
Mar 21, 2021·Thrombosis and Haemostasis·Jun WanMark Roest
Jun 30, 2021·International Journal of Laboratory Hematology·Tanmya SharmaCatherine P M Hayward
Sep 10, 2021·Arteriosclerosis, Thrombosis, and Vascular Biology·Gina PerrellaJohan W M Heemskerk

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