Interplay between receptor tyrosine kinases and hypoxia signaling in cancer

The International Journal of Biochemistry & Cell Biology
Astrid A GlückMichaela Medová

Abstract

Deregulated signaling via receptor tyrosine kinase (RTK) pathways is prevalent in numerous types of human cancers and is commonly correlated with worst prognosis, resistance to various treatment modalities and increased mortality. Likewise, hypoxic tumors are often manifested by aggressive mode of growth and progression following an adaptive genetic reprogramming with consequent transcriptional activation of genes encoding proteins, which support tumor survival under low oxygen-related conditions. Consequently, both the hypoxia-inducible factor (HIF) system, which is the major mediator of hypoxia-related signaling, and numerous RTK systems are considered critical molecular targets in current cancer therapy. It is now evident that there is an intricate molecular crosstalk between RTKs and hypoxia-related signaling in the sense that hypoxia can activate expression of particular RTKs and/or their corresponding ligands, while some RTK systems have been shown to trigger activation of the HIF machinery. Moreover, signaling regulation of some RTK systems under hypoxic conditions has also been documented to take place in a HIF-independent manner. With this review we aim at overviewing the most current observations on that topic and hig...Continue Reading

References

Jan 1, 1992·Annual Review of Physiology·S J Pilkis, D K Granner
Aug 19, 1991·International Journal of Cancer. Journal International Du Cancer·F RilkeA Testori
Apr 20, 1990·Cell·A Ullrich, J Schlessinger
Aug 1, 1995·Nature Medicine·O IliopoulosW G Kaelin
Feb 15, 1995·JAMA : the Journal of the American Medical Association·W M LinehanB Zbar
Mar 15, 1993·The Biochemical Journal·F BontempsG Van den Berghe
Feb 2, 1996·The Journal of Biological Chemistry·A P LevyM A Goldberg
Aug 1, 1996·Cytokine & Growth Factor Reviews·V A BlakesleyD Le Roith
May 23, 1997·Science·L ZhangK W Kinzler
Feb 7, 1998·The Journal of Clinical Investigation·D K MoscatelloR V Iozzo
Oct 31, 1998·Current Opinion in Genetics & Development·G L Semenza
Feb 13, 1999·The Journal of Biological Chemistry·R V IozzoI Eichstetter
Mar 5, 1999·Breast Cancer Research and Treatment·M D PegramD J Slamon
Jun 29, 2000·Oncogene·A FollenziP M Comoglio
Sep 6, 2001·Journal of the National Cancer Institute·A LalG J Riggins
Mar 21, 2002·Nature Reviews. Cancer·Adrian L Harris
Jul 3, 2002·Nature Reviews. Cancer·Igor Vivanco, Charles L Sawyers
Apr 3, 2003·Journal of the National Cancer Institute·Eun-Jin YeoJong-Wan Park
May 3, 2003·Cancer Cell·Selma PennacchiettiPaolo M Comoglio
Mar 17, 2004·Seminars in Cancer Biology·Arthur M MercurioJun Chung
Jul 16, 2004·Seminars in Radiation Oncology·Peter Vaupel
Jan 18, 2005·Trends in Biochemical Sciences·Laura S HarringtonRichard F Lamb

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Citations

Feb 13, 2016·The AAPS Journal·Rosamaria LappanoErnestina Marianna De Francesco
Jan 27, 2016·Cancer Chemotherapy and Pharmacology·Roger M Phillips
Mar 28, 2019·Genome Medicine·Adrià Fernández-TorrasPatrick Aloy
Jul 17, 2021·Proceedings of the National Academy of Sciences of the United States of America·Marie-Anne GoyetteJean-François Côté

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