Interplay between the androgen receptor signalling axis and microRNAs in prostate cancer

Endocrine-related Cancer
Rayzel FernandesLuke A Selth

Abstract

The androgen receptor (AR) is a ligand activated transcription factor that drives prostate cancer. Since therapies that target the AR are the mainstay treatment for men with metastatic disease, it is essential to understand the molecular mechanisms underlying oncogenic AR signaling in the prostate. MicroRNAs (miRNAs) are small, non-coding regulators of gene expression that play a key role in prostate cancer, and are increasingly recognized as targets or modulators of the AR signaling axis. In this review, we examine the regulation of AR signalling by miRNAs and vice versa, and discuss how this interplay influences prostate cancer growth, metastasis and resistance to therapy. Finally, we explore the potential clinical applications of miRNAs implicated in the regulation of AR signaling in this prevalent hormone-driven disease.

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Citations

Dec 15, 2020·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ke LuYongchang Chen
Oct 28, 2020·Proceedings of the National Academy of Sciences of the United States of America·Jordan E VellkyWilliam A Ricke
Aug 4, 2020·Asian Journal of Urology·Ieva EringyteClaire E Fletcher

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