Interplay Effect of Target Motion and Pencil-Beam Scanning in Proton Therapy for Pediatric Patients

International Journal of Particle Therapy
Andrew J BoriaChia-Ho Hua

Abstract

To investigate the effect of interplay between spot-scanning proton beams and respiration-induced tumor motion on internal target volume coverage for pediatric patients. Photon treatments for 10 children with representative tumor motions (1-13 mm superior-inferior) were replanned to simulate single-field uniform dose- optimized proton therapy. Static plans were designed by using average computed tomography (CT) data sets created from 4D CT data to obtain nominal dose distributions. The motion interplay effect was simulated by assigning each spot in the static plan delivery sequence to 1 of 10 respiratory-phase CTs, using the actual patient breathing trace and specifications of a synchrotron-based proton system. Dose distributions for individual phases were deformed onto the space of the average CT and summed to produce the accumulated dose distribution, whose dose-volume histogram was compared with the one from the static plan. Tumor motion had minimal impact on the internal target volume hot spot (D2), which deviated by <3% from the nominal values of the static plans. The cold spot (D98) was also minimally affected, except in 2 patients with diaphragmatic tumor motion exceeding 10 mm. The impact on tumor coverage was more pron...Continue Reading

References

Apr 4, 2006·International Journal of Radiation Oncology, Biology, Physics·Martijn EngelsmanHanne M Kooy
Nov 20, 2009·IEEE Transactions on Medical Imaging·Stefan KleinJosien P W Pluim
May 31, 2011·International Journal of Radiation Oncology, Biology, Physics·Atmaram S Pai PanandikerThomas E Merchant
May 11, 2012·Physics in Medicine and Biology·Harald Paganetti
Oct 4, 2012·Health Physics·Anita Mahajan
Feb 11, 2014·Medical Physics·Yupeng LiXiaodong Zhang
Sep 28, 2014·International Journal of Radiation Oncology, Biology, Physics·Joe Y ChangXiaodong Zhang
Apr 17, 2016·International Journal of Radiation Oncology, Biology, Physics·Kinga BernatowiczAntony Lomax
Oct 19, 2016·Physics in Medicine and Biology·Jinsoo UhChiaho Hua
Apr 2, 2017·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Sophie C HuijskensArjan Bel
Aug 18, 2017·International Journal of Radiation Oncology, Biology, Physics·Jinsoo UhChiaho Hua

❮ Previous
Next ❯

Citations

Jan 11, 2020·Radiation Oncology Journal·Youngyih Han
Nov 24, 2020·Physics in Medicine and Biology·Harald PaganettiTony Lomax
Mar 18, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Gyu Sang YooHojeong Won
Feb 23, 2020·Clinical Oncology : a Journal of the Royal College of Radiologists·P S LimD C Weber

❮ Previous
Next ❯

Methods Mentioned

BETA
sedation

Software Mentioned

Eclipse
MIM
elastix

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.