Interplay of autophagy and apoptosis during PRRSV infection of Marc145 cell

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
Shuaifeng LiShujun Zhang

Abstract

Autophagy and apoptosis play essential roles 'in virus infection. Our study was performed to investigate the interplay between autophagy and apoptosis in PRRSV replication. In our present study, autophagy and apoptosis were induced by PRRSV infection. Viral replication was dampened/attenuated by autophagy deficient and potentiated by apoptosis inhibition. Furthermore, PRRSV replication was restored by apoptosis inhibition in autophagy deficient cells. Taken together, our findings unveil the functional relationship between autophagy and apoptosis during PRRSV replication.

References

Jul 6, 2007·Autophagy·Noboru Mizushima, Tamotsu Yoshimori
Aug 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Marlène DreuxFrancis V Chisari
Nov 16, 2010·Cell Host & Microbe·Nicholas S Heaton, Glenn Randall
Apr 18, 2012·The Journal of Experimental Medicine·Pierre-Emmanuel JoubertMatthew L Albert
Jan 10, 2014·Nature Reviews. Molecular Cell Biology·Guillermo MariñoGuido Kroemer

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Citations

Jul 12, 2017·Viruses·Yingying CongFulvio Reggiori
Jan 30, 2019·Virology Journal·Wei ZhangXiaohong Liu
Aug 20, 2020·Veterinary Research·Shengliang CaoYihong Xiao

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