Interplay of cigarette smoking and occupational exposure on specific immunoglobulin E antibodies to cobalt

Archives of Environmental Health
T Shirakawa, K Morimoto


The results of a cross-sectional survey of an occupational population (n = 706) exposed to hard metal dust revealed distribution of specific immunoglobulin E antibodies against cobalt-conjugated serum albumin (Co-HSA). This population was segregated with respect to smoking and dust-exposure doses. Standard deviations (0.08-0.13) of Co-HSA RAST were sufficiently small (< 7%) to warrant reproducibility. Confirming evidence for 8 workers who had mean + 3 standard deviations of Co-HSA RAST indices and who had been diagnosed with occupational asthma also provided better sensitivity (8/19) and specificity (687/687) of hard metal asthma, rather than metal-induced asthma. Cobalt exposure resulted in significant increases in Co-HSA RAST indices in males, whose mean index was 1.16 +/- 0.13 in nonexposed subjects and 1.37 +/- 0.13 in exposed subjects. There was no difference, however, in the females. This difference between males and females cannot be explained by differences in ages or dust-exposure doses. Furthermore, the specific RAST indices against Co-HSA displayed a strong correlation not only to the intensity of cobalt exposure (r = .488, p < .001), but to log(total exposure doses) (r = .578, p < .001). These results suggest that C...Continue Reading


Mar 1, 1979·Clinical Allergy·O CromwellE G Hughes
Jan 1, 1991·Social Science & Medicine·A Hagihara, K Morimoto
Sep 1, 1988·Clinical Allergy·T ShirakawaK Morimoto
Sep 1, 1984·The Journal of Allergy and Clinical Immunology·A CartierJ Y Dubois
Nov 7, 1981·British Medical Journal·O ZetterströmS G Johansson

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Jul 14, 2000·American Journal of Industrial Medicine·V van KampenX Baur

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